1-methyl-4-nitro-5-imidazolyl-2-chloro-6-methylphenyl sulfone

Base Information

• Chemical Name: 1-methyl-4-nitro-5-imidazolyl-2-chloro-6-methylphenyl sulfone
• CAS No.: 131134-91-3
• Molecular Formula: C11H10 Cl N3 O4 S
• Molecular Weight: 0
• Mol file: 131134-91-3.mol

Synonyms:1-methyl-4-nitro-5-imidazolyl-2-chloro-6-methylphenyl sulfone

Chemical Property of 1-methyl-4-nitro-5-imidazolyl-2-chloro-6-methylphenyl sulfone

Chemical Property:

• Vapor Pressure: 1.67E-13mmHg at 25°C
• Boiling Point: 595.1°Cat760mmHg
• Flash Point: 313.7°C
• PSA: 191.52000
• Density: 1.56g/cm³
• LogP: 6.00260

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-methyl-4-nitro-5-imidazolyl-2-chloro-6-methylphenyl sulfone

There total 2 articles about 1-methyl-4-nitro-5-imidazolyl-2-chloro-6-methylphenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-methyl-4-nitro-5-imidazolyl 2-chloro-6-methylphenyl sulfide (135216-93-2) → 1-methyl-4-nitro-5-imidazolyl 2-chloro-6-methylphenyl sulfone (131134-91-3)

Guidance literature:

With dihydrogen peroxide; In acetic acid; for 21.5h; 1.) 60 deg C, 3 h, 2.) 70 deg C, 18 h, 3.) 80 deg C, 0.5 h;

DOI:10.1002/jps.2600791003

Reference yield:

2-chloro-6-methylbenzenethiol (18858-05-4) → 1-methyl-4-nitro-5-imidazolyl 2-chloro-6-methylphenyl sulfone (131134-91-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NH₃ / ethanol / a) 50 deg C, b) room temp., 3 h

2: 79 percent / 30percent aq. H₂O₂ / acetic acid / a) 60 deg C, 3 h, b) 70 deg C, 18 h, c) 80 deg C, 0.5 h

With ammonia; dihydrogen peroxide; In ethanol; acetic acid;

DOI:10.1002/jhet.5570280307

Reference yield:

glutathion (70-18-8) + 1-methyl-4-nitro-5-imidazolyl 2-chloro-6-methylphenyl sulfone (131134-91-3) → 2-Chlor-6-methylbenzolsulfinsaeure + N-[N-L-γ-glutamyl-S-(3-methyl-5-nitro-3H-imidazol-4-yl)-L-cysteinyl]-glycine (36892-55-4)

Guidance literature:

at 37 ℃; Rate constant; Kinetics; also in the presence of var. liposomes;

DOI:10.1002/jps.2600791003

upstream raw materials:

1-methyl-4-nitro-5-imidazolyl 2-chloro-6-methylphenyl sulfide

2-chloro-6-methylbenzenethiol

Downstream raw materials:

N-[N-L-γ-glutamyl-S-(3-methyl-5-nitro-3H-imidazol-4-yl)-L-cysteinyl]-glycine

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