N-dichlorophosphinothioylpropan-2-amine

Base Information

• Chemical Name: N-dichlorophosphinothioylpropan-2-amine
• CAS No.: 50822-49-6
• Molecular Formula: C3H8Cl2NPS
• Molecular Weight: 192.0471
• NSC Number: 158049
• DSSTox Substance ID: DTXSID50965054
• Wikidata: Q82947221
• Mol file: 50822-49-6.mol

Synonyms:50822-49-6;NSC158049;DTXSID50965054;NSC-158049;N-Propan-2-ylphosphoramidothioic dichloride

Chemical Property of N-dichlorophosphinothioylpropan-2-amine

Chemical Property:

• Vapor Pressure: 0.205mmHg at 25°C
• Boiling Point: 209.3°Cat760mmHg
• Flash Point: 80.4°C
• Density: 1.352g/cm³
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 190.9492128
• Heavy Atom Count: 8
• Complexity: 110

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)NP(=S)(Cl)Cl

Technology Process of N-dichlorophosphinothioylpropan-2-amine

There total 1 articles about N-dichlorophosphinothioylpropan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

isopropylamine (75-31-0) → N-isopropylphosphoramidic dichloridothioate (50822-49-6)

Guidance literature:

With triethylamine; trichlorophosphate; In diethyl ether; Ambient temperature;

Reference yield:

N-isopropylphosphoramidic dichloridothioate (50822-49-6) + 2-hydroxy-5-methyl-3-nitrobenzenemethanol (91084-83-2) → 2-isopropyl-(6-methyl-8-nitro-2-thioxo-4H-2λ5-benzo[1,3,2]dioxaphosphininyl)-amine (1437305-94-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmcl.2013.04.026

Reference yield:

2-hydroxy-5-nitrobenzyl alcohol (39224-61-8) + N-isopropylphosphoramidic dichloridothioate (50822-49-6) → 2-isopropyl-(6-nitro-2-thioxo-4H-2λ5-benzo[1,3,2]dioxaphosphininyl)-amine (99300-63-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmcl.2013.04.026

upstream raw materials:

isopropylamine

Downstream raw materials:

isopropyl-amidothiophosphoric acid O-ethyl ester-O'-(4-nitro-phenyl ester)

isopropyl-amidothiophosphoric acid O-ethyl ester-O'-(2,4,6-trichloro-phenyl ester)

N-isopropyl-N'-methyl-diamidothiophosphoric acid O-(2,4,5-trichloro-phenyl ester)

isopropyl-amidothiophosphoric acid O-ethyl ester-O'-(2,4,5-trichloro-phenyl ester)