5α-Hydroxy-11-methoxy-1-methyl-9,10-(methylenebisoxy)lycorenan-7-one

Base Information

• Chemical Name: 5α-Hydroxy-11-methoxy-1-methyl-9,10-(methylenebisoxy)lycorenan-7-one
• CAS No.: 1167-58-4
• Molecular Formula: C₁₈H₁₉NO₆
• Molecular Weight: 345.352
• Mol file: 1167-58-4.mol

Synonyms:Neronine;Neronin;

Chemical Property of 5α-Hydroxy-11-methoxy-1-methyl-9,10-(methylenebisoxy)lycorenan-7-one

Chemical Property:

• Melting Point: 196-7°C
• PSA: 77.46000
• LogP: 0.98940

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: This alkaloid possesses a similar structure to that of Nerinine (q.v.) and is found in Nerine krigeii. It may be crystallized from AcOEt and is dextrorotatory with [0:]54 + 161.6° (c 0.57, CHC13). It is hygroscopic and behaves as a monoacidic base yielding a picrate as yellow prisms, m.p. 205-9°C (dec.); a methiodide, m.p. 260-5°C (dec.) and a crystalline O-acetate, m.p. 20t-2°C. It contains a lactone ring which may be opened by alkalies and regenerated by acids.

Technology Process of 5α-Hydroxy-11-methoxy-1-methyl-9,10-(methylenebisoxy)lycorenan-7-one

There total 2 articles about 5α-Hydroxy-11-methoxy-1-methyl-9,10-(methylenebisoxy)lycorenan-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 5α,11-dihydroxy-9,10-methanediyldioxy-1-methyl-lycoran-4(12)-en-7-one (10313-70-9) → Neronin (1167-58-4)

Guidance literature:

In methanol; diethyl ether;

DOI:10.1016/S0040-4039(00)70063-3

Reference yield:

→ Neronin (1167-58-4)

Guidance literature:

Krigein, Al2O3 (Artefakt bei der Isol. von Alkaloiden aus Nerine krigeii);

upstream raw materials:

diazomethane

5α,11-dihydroxy-9,10-methanediyldioxy-1-methyl-lycoran-4(12)-en-7-one