1-[2-(3-BROMOPHENOXY)ETHYL]-PYRROLIDINE

Base Information

• Chemical Name: 1-[2-(3-BROMOPHENOXY)ETHYL]-PYRROLIDINE
• CAS No.: 23136-18-7
• Molecular Formula: C12H16 Br N O
• Molecular Weight: 270.169
• Hs Code.: 2933990090
• Mol file: 23136-18-7.mol

Synonyms:Pyrrolidine,1-[2-(m-bromophenoxy)ethyl]- (8CI); 1-[2-(3-Bromophenoxy)ethyl]pyrrolidine

Chemical Property of 1-[2-(3-BROMOPHENOXY)ETHYL]-PYRROLIDINE

Chemical Property:

• Vapor Pressure: 9.08E-05mmHg at 25°C
• Boiling Point: 339.6°Cat760mmHg
• PKA: 9.58±0.20(Predicted)
• Flash Point: 159.2°C
• PSA: 12.47000
• Density: 1.337g/cm³
• LogP: 2.86160
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-[2-(3-Bromophenoxy)ethyl]pyrrolidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[2-(3-BROMOPHENOXY)ETHYL]-PYRROLIDINE

There total 1 articles about 1-[2-(3-BROMOPHENOXY)ETHYL]-PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

3-Bromophenol (591-20-8) + 1-(2-chloroethyl)pyrrolidine hydrochloride (7250-67-1) → 1-[2-(3-bromophenoxy)ethyl]pyrrolidine (23136-18-7)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); for 48h;

Reference yield: 83.0%

1-[2-(3-bromophenoxy)ethyl]pyrrolidine (23136-18-7) + 5-nitropyrimidin-2-amine (3073-77-6) → N2-(3-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrimidine-2,5-diamine (910907-13-0)

Guidance literature:

1-[2-(3-bromophenoxy)ethyl]pyrrolidine; 5-nitropyrimidin-2-amine; With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 2h; Heating / reflux;

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1h;

Reference yield: 70.0%

1-[2-(3-bromophenoxy)ethyl]pyrrolidine (23136-18-7) + 7-(2,6-dimethylphenyl)-5-methyl-1,2,4-benzotriazine-3-ylamine (867333-35-5) → [7-(2,6-dimethyl-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[3-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine

Guidance literature:

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 12h; Heating;

DOI:10.1016/j.bmcl.2006.08.035

upstream raw materials:

3-Bromophenol

1-(2-chloroethyl)pyrrolidine hydrochloride

Downstream raw materials:

N₂-(3-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrimidine-2,5-diamine

methyl 2-((3-(2-pyrrolidin-1-ylethoxy)phenyl)amino)pyrimidine-5-carboxylate

2-(3-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)-4-aminopyrimidine-5-carbonitrile

N-(2-(3-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-5-yl)-5-bromo-2-chlorobenzamide

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