Cyclopentanemethanol, 3-(5,7-diamino-3H-1,2,3-triazolo(4,5-d)pyrimidin-3-yl)-4-hydroxy-, rel-(1S,3R,4R)-

Base Information

Chemical Name:Cyclopentanemethanol, 3-(5,7-diamino-3H-1,2,3-triazolo(4,5-d)pyrimidin-3-yl)-4-hydroxy-, rel-(1S,3R,4R)-
CAS No.:106762-91-8
Molecular Formula:C₁₀H₁₅N₇O₂
Molecular Weight:265.275
Hs Code.:
DSSTox Substance ID:DTXSID70147754
Wikidata:Q83013143

Synonyms:C-8-Aza-2,6-DAP-3'-dR;106762-91-8;Cyclopentanemethanol, 3-(5,7-diamino-3H-1,2,3-triazolo(4,5-d)pyrimidin-3-yl)-4-hydroxy-, rel-(1S,3R,4R)-;Cyclopentanemethanol, 3-(5,7-diamino-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-4-hydroxy-, rel-(1S,3R,4R)-;DTXSID70147754;(1R,2R,4S)-2-(5,7-diaminotriazolo[4,5-d]pyrimidin-3-yl)-4-(hydroxymethyl)cyclopentanol

Suppliers and Price of Cyclopentanemethanol, 3-(5,7-diamino-3H-1,2,3-triazolo(4,5-d)pyrimidin-3-yl)-4-hydroxy-, rel-(1S,3R,4R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclopentanemethanol, 3-(5,7-diamino-3H-1,2,3-triazolo(4,5-d)pyrimidin-3-yl)-4-hydroxy-, rel-(1S,3R,4R)-

Chemical Property:

Vapor Pressure:1.1E-20mmHg at 25°C
Boiling Point:702°Cat760mmHg
Flash Point:378.4°C
Density:2.1g/cm³
XLogP3:-1.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:2
Exact Mass:265.12872275
Heavy Atom Count:19
Complexity:333

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(CC(C1N2C3=NC(=NC(=C3N=N2)N)N)O)CO
Isomeric SMILES:C1[C@@H](C[C@H]([C@@H]1N2C3=NC(=NC(=C3N=N2)N)N)O)CO

Technology Process of Cyclopentanemethanol, 3-(5,7-diamino-3H-1,2,3-triazolo(4,5-d)pyrimidin-3-yl)-4-hydroxy-, rel-(1S,3R,4R)-

There total 5 articles about Cyclopentanemethanol, 3-(5,7-diamino-3H-1,2,3-triazolo(4,5-d)pyrimidin-3-yl)-4-hydroxy-, rel-(1S,3R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 106762-87-2
(+/-)-(1α,3α,4β)-3-(5-amino-7-chloro-3H-1,2,3-triazolo<4,5-d>pyrimidin-3-yl)-4-hydroxycyclopentanemethanol

: 106762-91-8
(+/-)-(1α,3α,4β)-3-(5,7-diamino-3H-1,2,3-triazolo<4,5-d>pyrimidin-3-yl)-4-hydroxycyclopentanemethanol

Guidance literature:: With ammonia; at 60 ℃; for 18h;
DOI:10.1021/jm00389a019

Reference yield:

: 68715-64-0
(+/-)-(1α,3α,4β)-3-amino-4-hydroxycyclopentanemethanol

: 106762-91-8
(+/-)-(1α,3α,4β)-3-(5,7-diamino-3H-1,2,3-triazolo<4,5-d>pyrimidin-3-yl)-4-hydroxycyclopentanemethanol

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / ethanol / 24 h / Heating

2: 1. NaN₃, aq. HCl, 2.) sodium acetate trihydrate, acetic acid / 1.) 0 deg C, 2.) H₂O, RT

3: 71 percent / Zn / acetic acid; H₂O; ethanol / 1.5 h / 70 °C

4: 67 percent / NaN₃ / H₂O; acetic acid / 1 h / 0 °C

5: 77 percent / NH₃ / 18 h / 60 °C

With hydrogenchloride; sodium azide; ammonia; sodium acetate; acetic acid; triethylamine; zinc; In ethanol; water; acetic acid;
DOI:10.1021/jm00389a019

Reference yield:

: 106762-85-0
(+/-)-(1α,3α,4β)-3-<(2,5-diamino-6-chloro-4-pyrimidinyl)amino>-4-hydroxycyclopentanemethanol

: 106762-91-8
(+/-)-(1α,3α,4β)-3-(5,7-diamino-3H-1,2,3-triazolo<4,5-d>pyrimidin-3-yl)-4-hydroxycyclopentanemethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / NaN₃ / H₂O; acetic acid / 1 h / 0 °C

2: 77 percent / NH₃ / 18 h / 60 °C

With sodium azide; ammonia; In water; acetic acid;
DOI:10.1021/jm00389a019