2-(2-Chloro-4-ethylphenoxy)-5-methylbenzeneacetic acid

Base Information

• Chemical Name: 2-(2-Chloro-4-ethylphenoxy)-5-methylbenzeneacetic acid
• CAS No.: 34643-09-9
• Molecular Formula: C₁₇H₁₇ClO₃
• Molecular Weight: 304.773
• Hs Code.: 2918990090
• Mol file: 34643-09-9.mol

Synonyms:

Chemical Property of 2-(2-Chloro-4-ethylphenoxy)-5-methylbenzeneacetic acid

Chemical Property:

• Vapor Pressure: 1.47E-07mmHg at 25°C
• Boiling Point: 412.9°C at 760 mmHg
• Flash Point: 203.5°C
• PSA: 46.53000
• Density: 1.226g/cm³
• LogP: 4.63020

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-Chloro-4-ethylphenoxy)-5-methylbenzeneacetic acid

There total 5 articles about 2-(2-Chloro-4-ethylphenoxy)-5-methylbenzeneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[2-(2-Chloro-4-ethyl-phenoxy)-5-methyl-phenyl]-1-morpholin-4-yl-ethanethione → [2-(2-Chloro-4-ethyl-phenoxy)-5-methyl-phenyl]-acetic acid (34643-09-9)

Guidance literature:

With potassium hydroxide; In methanol; for 72h; Heating;

DOI:10.1021/jm00364a004

Reference yield:

2'-chloro-5-methylacetophenone (73129-52-9) → [2-(2-Chloro-4-ethyl-phenoxy)-5-methyl-phenyl]-acetic acid (34643-09-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 2-chloro-4-ethylphenol, copper / 24 h / 120 - 125 °C

2: sulfur / 24 h / Heating

3: KOH / methanol / 72 h / Heating

With potassium hydroxide; 2-chloro-4-ethylphenol; copper; sulfur; In methanol;

DOI:10.1021/jm00364a004

Reference yield:

1-[2-(2-Chloro-4-ethyl-phenoxy)-5-methyl-phenyl]-ethanone → [2-(2-Chloro-4-ethyl-phenoxy)-5-methyl-phenyl]-acetic acid (34643-09-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfur / 24 h / Heating

2: KOH / methanol / 72 h / Heating

With potassium hydroxide; sulfur; In methanol;

DOI:10.1021/jm00364a004

upstream raw materials:

para-chlorotoluene

acetyl chloride

2'-chloro-5-methylacetophenone

Refernces