(7R,9aS)-1,2,3,8,9,9a-Hexahydro-6-hydroxy-3',5-dimethoxy-1-methylspiro[7H-benzo[de]quinoline-7,1'-[2,5]cyclohexadien]-4'-one

Base Information

Chemical Name:(7R,9aS)-1,2,3,8,9,9a-Hexahydro-6-hydroxy-3',5-dimethoxy-1-methylspiro[7H-benzo[de]quinoline-7,1'-[2,5]cyclohexadien]-4'-one
CAS No.:17441-87-1
Molecular Formula:C₂₀H₂₃NO₄
Molecular Weight:341.407
Hs Code.:
Mol file:17441-87-1.mol

Synonyms:

Suppliers and Price of (7R,9aS)-1,2,3,8,9,9a-Hexahydro-6-hydroxy-3',5-dimethoxy-1-methylspiro[7H-benzo[de]quinoline-7,1'-[2,5]cyclohexadien]-4'-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (7R,9aS)-1,2,3,8,9,9a-Hexahydro-6-hydroxy-3',5-dimethoxy-1-methylspiro[7H-benzo[de]quinoline-7,1'-[2,5]cyclohexadien]-4'-one

Chemical Property:

Boiling Point:529.5°Cat760mmHg
Flash Point:274°C
Density:1.3g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (7R,9aS)-1,2,3,8,9,9a-Hexahydro-6-hydroxy-3',5-dimethoxy-1-methylspiro[7H-benzo[de]quinoline-7,1'-[2,5]cyclohexadien]-4'-one

There total 4 articles about (7R,9aS)-1,2,3,8,9,9a-Hexahydro-6-hydroxy-3',5-dimethoxy-1-methylspiro[7H-benzo[de]quinoline-7,1'-[2,5]cyclohexadien]-4'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 75091-29-1
1,2,3,4-tetrahydro-7-hydroxy-1-(4-hydroxy-3-methoxyphenethyl)-6-methoxy-2-methylisoquinoline N-oxide

: 23180-40-7
1-(3-hydroxy-4-methoxy-phenethyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ol

: 14897-74-6,17441-86-0,17441-87-1,30040-57-4,51744-25-3
(+/-)-kreysigonones

Guidance literature:: With copper(l) chloride; In methanol; at 10 - 15 ℃; for 24h;

Reference yield:

: 1-[2-(4-Hydroxy-3-methoxy-phenyl)-ethyl]-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ol

: 14897-74-6,17441-86-0,17441-87-1,30040-57-4,51744-25-3
(+/-)-kreysigonones

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 2 h / Ambient temperature

2: CuCl / methanol / 24 h / 10 - 15 °C

With 3-chloro-benzenecarboperoxoic acid; copper(l) chloride; In methanol; dichloromethane;

Reference yield:

: 14897-74-6,17441-86-0,17441-87-1,30040-57-4,51744-25-3
(+/-)-kreysigonones

Guidance literature:: 1-<2-(4-Hydroxy-3-methoxy-phenyl)-ethyl>-2-methyl-6-methoxy-7-hydroxy-1,2,3,4-tetrahydro-isochinolin, K3, neben 5,2'-Dimethoxy-1'-oxo-1-methyl-6-hydroxy-2,3,7,8,9,9a-hexahydro-1H-benzochinolin<7-spiro-4'>cyclo;
DOI:10.1039/C19670000878