Chemical Property of Picroside I
Chemical Property:
- Vapor Pressure:1.62E-25mmHg at 25°C
- Refractive Index:1.671
- Boiling Point:778.6 °C at 760 mmHg
- Flash Point:267.5 °C
- PSA：167.67000
- Density:1.56 g/cm3
- LogP:-1.32600
- Storage Temp.:2-8°C
- Solubility.:ethanol: soluble1mg/mL, clear, colorless
- XLogP3:-1.1
- Hydrogen Bond Donor Count:5
- Hydrogen Bond Acceptor Count:11
- Rotatable Bond Count:8
- Exact Mass:492.16316171
- Heavy Atom Count:35
- Complexity:826
- Purity/Quality:
-
≥98% *data from raw suppliers
Picroside I *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC=C(C=C1)C=CC(=O)OCC2C(C(C(C(O2)OC3C4C(C=CO3)C(C5C4(O5)CO)O)O)O)O
- Isomeric SMILES:C1=CC=C(C=C1)/C=C/C(=O)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4[C@@H](C=CO3)[C@@H]([C@H]5[C@@]4(O5)CO)O)O)O)O
-
Description
Picroliv is a hepatoprotective mixture of compounds that is isolated from an herb native to the Himalayas. Picroside I is an iridoid glycoside found in picroliv. By itself, picroside I blocks changes in acid phosphatase activity, phospholipid levels, and lipid peroxide production induced by D-galactosamine in rat liver. Picroside I also enhances neurite outgrowth in PC12D cells induced by basic fibroblast growth factor and 7S nerve growth factor when given at 60 μM. At concentrations as low as 5 μM, picroside I enhances the ATPase activity of the efflux transporter P-glycoprotein.
-
Uses
Picroside I acts as an oxygen free radical scavenger and thus promotes anti-inflammatory activity and may be used in the treatment of arthritis.
