2-(aminomethyl)-1,3-thiazole-4-carboxylic Acid Hydrochloride

Base Information

Chemical Name:2-(aminomethyl)-1,3-thiazole-4-carboxylic Acid Hydrochloride
CAS No.:63628-60-4
Molecular Formula:C5H6N2O2S
Molecular Weight:158.1783
Hs Code.:
European Community (EC) Number:869-319-8
NSC Number:143131
DSSTox Substance ID:DTXSID90435281

Synonyms:63628-60-4;2-(aminomethyl)-1,3-thiazole-4-carboxylic Acid Hydrochloride;NSC143131;2-(aminomethyl)-1,3-thiazole-4-carboxylic acid;hydrochloride;SCHEMBL23120712;DTXSID90435281;NSC-143131;EN300-321152;2-(aminomethyl)-1,3-thiazole-4-carboxylicAcidHydrochloride

Suppliers and Price of 2-(aminomethyl)-1,3-thiazole-4-carboxylic Acid Hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 5 raw suppliers

Chemical Property of 2-(aminomethyl)-1,3-thiazole-4-carboxylic Acid Hydrochloride

Chemical Property:

Vapor Pressure:1.89E-05mmHg at 25°C
Boiling Point:348.4°Cat760mmHg
Flash Point:164.5°C
Density:1.511g/cm³
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:193.9916763
Heavy Atom Count:11
Complexity:142

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(N=C(S1)CN)C(=O)O.Cl

Technology Process of 2-(aminomethyl)-1,3-thiazole-4-carboxylic Acid Hydrochloride

There total 2 articles about 2-(aminomethyl)-1,3-thiazole-4-carboxylic Acid Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 71904-80-8
2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxylic acid

: 63628-60-4
2-(aminomethyl)thiazole-4-carboxylic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 23 ℃; for 1h;
DOI:10.1021/jacs.6b02276

Reference yield: 90.0%

: 88219-00-5
ethyl 2-(benzamidomethyl)thiazole-4-carboxylate

: 63628-60-4
2-(aminomethyl)thiazole-4-carboxylic acid hydrochloride

Guidance literature:: With hydrogenchloride; for 16h; Heating;
DOI:10.1021/jo00215a012

Reference yield:

: 63628-60-4
2-(aminomethyl)thiazole-4-carboxylic acid hydrochloride

: 96394-11-5,96479-26-4
(S)-1-((S)-2-{(S)-2-[(2-{1-[(2-Aminomethyl-thiazole-4-carbonyl)-amino]-3-carbamoyl-propyl}-thiazole-4-carbonyl)-amino]-3-methyl-butyrylamino}-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid 2,4,5-trichloro-phenyl ester; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) sodium hydroxide / 1.) dioxane, 3 h, 0 deg C, 2.) 1 h, RT

2: 1.) hydroxybenzotriazole, dicyclohexylcarbodiimide, 2.) N-methylmorpholine / 1.) a) tetrahydrofuran,1 h, 0 deg C, b) 1 h, RT, 2.) dimethyloformamide, 16 h, RT

3: aq. sodium hydroxide / dioxane / 7 h / Ambient temperature

4: 109 mg / dicyclohexylcarbodiimide / 1,2-dimethoxy-ethane / 3 h / Ambient temperature

5: 1.) methylene chloride, RT, 1h, 2.) carbon tetrachloride, 1 h

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; 1,2-dimethoxyethane;
DOI:10.1021/jo00215a012