2'-deoxy-8,2'-methylene-cycloguanosine

Base Information

Chemical Name:2'-deoxy-8,2'-methylene-cycloguanosine
CAS No.:99921-84-3
Molecular Formula:C₁₁H₁₃N₅O₄
Molecular Weight:279.255
Hs Code.:

Synonyms:

Suppliers and Price of 2'-deoxy-8,2'-methylene-cycloguanosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 1 raw suppliers

Chemical Property of 2'-deoxy-8,2'-methylene-cycloguanosine

Chemical Property:

Boiling Point:726.6°Cat760mmHg
Flash Point:393.2°C
PSA：139.28000
Density:2.41g/cm³
LogP:-1.29410

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2'-deoxy-8,2'-methylene-cycloguanosine

There total 20 articles about 2'-deoxy-8,2'-methylene-cycloguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 121783-31-1
3',5'-di-O-acetyl-2'-deoxy-8,2'-methanoguanosine

: 99921-84-3
2'-deoxy-8,2'-methanoguanosine

Guidance literature:: With ammonia; In methanol; for 24h; Ambient temperature;
DOI:10.1248/cpb.37.298

Reference yield:

: 30747-23-0
Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(2-acetylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

: 99921-84-3
2'-deoxy-8,2'-methanoguanosine

Guidance literature:: Multi-step reaction with 16 steps

1: triphenylphosphine, diethyl azodicarboxylate / dioxane / 0.5 h / Ambient temperature

2: ammonia / methanol / Ambient temperature

3: 97.5 percent / ammonia / methanol / 24 h / 65 °C / in a sealed tube

4: 68.4 percent / NBS / dimethylformamide / 2 h / Ambient temperature

5: H₂O; dimethylformamide / 24 h / Ambient temperature

6: DMAP, pyridine / 24 h / Heating

7: ammonia / methanol / 8 h / Ambient temperature

8: 1.) dibutyltin oxide; 2.) triethylamine / 1.) methanol, reflux, 2 h; 2.) methanol, r.t., 3 h

9: triethylamine, DMAP / acetonitrile / 1 h / Ambient temperature

10: m-chloroperoxybenzoic acid / CH₂Cl₂ / 3 h / Ambient temperature

11: 88.1 percent / 60percent NaH in mineral oil / tetrahydrofuran / 4 h / Heating

12: 1.) 85percent pridine; 2.) Et₃N, DMAP / 1.) H₂O, reflux, 1 d; 2.) CH₃CN, r.t., 1 h

13: 96.8 percent / ammonia / methanol / 36 h / 100 °C / in sealed glass tube

14: 95.3 percent / triethylamine, DMAP / acetonitrile / 1 h / Ambient temperature

15: 1.) NaI, trimethylsilyl chloride; 2.) triethylamine, DMAP / 1.) CH₃CN, r.t., 2 h; 2.) CH₃CN, r.t., 1 h

16: 85 percent / ammonia / methanol / 24 h / Ambient temperature

With pyridine; dmap; N-Bromosuccinimide; chloro-trimethyl-silane; ammonia; sodium hydride; di(n-butyl)tin oxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; sodium iodide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.37.298

Reference yield:

: 39708-01-5
2-amino-6-ethoxy-9-(β-D-ribofuranosyl)-9H-purine

: 99921-84-3
2'-deoxy-8,2'-methanoguanosine

Guidance literature:: Multi-step reaction with 13 steps

1: 68.4 percent / NBS / dimethylformamide / 2 h / Ambient temperature

2: H₂O; dimethylformamide / 24 h / Ambient temperature

3: DMAP, pyridine / 24 h / Heating

4: ammonia / methanol / 8 h / Ambient temperature

5: 1.) dibutyltin oxide; 2.) triethylamine / 1.) methanol, reflux, 2 h; 2.) methanol, r.t., 3 h

6: triethylamine, DMAP / acetonitrile / 1 h / Ambient temperature

7: m-chloroperoxybenzoic acid / CH₂Cl₂ / 3 h / Ambient temperature

8: 88.1 percent / 60percent NaH in mineral oil / tetrahydrofuran / 4 h / Heating

9: 1.) 85percent pridine; 2.) Et₃N, DMAP / 1.) H₂O, reflux, 1 d; 2.) CH₃CN, r.t., 1 h

10: 96.8 percent / ammonia / methanol / 36 h / 100 °C / in sealed glass tube

11: 95.3 percent / triethylamine, DMAP / acetonitrile / 1 h / Ambient temperature

12: 1.) NaI, trimethylsilyl chloride; 2.) triethylamine, DMAP / 1.) CH₃CN, r.t., 2 h; 2.) CH₃CN, r.t., 1 h

13: 85 percent / ammonia / methanol / 24 h / Ambient temperature

With pyridine; dmap; N-Bromosuccinimide; chloro-trimethyl-silane; ammonia; sodium hydride; di(n-butyl)tin oxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium iodide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.37.298