JK 409

Base Information

• Chemical Name: JK 409
• CAS No.: 76095-38-0
• Molecular Formula: C15H14O5
• Molecular Weight: 274.273
• Mol file: 76095-38-0.mol

Synonyms:4-methoxybenzyl 2,4,5-trihydroxyphenyl ketone;[4-Methoxy-benzyl]-[2,4,5-trihydroxy-phenyl]-keton;1-(2,4,5-trihydroxyphenyl)-2-(4-methoxyphenyl)ethanone;2,4,5-trihydroxy-4'-methoxydeoxybenzoin;2.4.5-Trihydroxy-ω-[4-methoxy-phenyl]-acetophenon;

Chemical Property of JK 409

Chemical Property:

• Melting Point: 180–181°C
• PSA: 86.99000
• LogP: 2.23740

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of JK 409

There total 6 articles about JK 409 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.6%

1,2,4-Trihydroxybenzene (533-73-3) + p-methoxybenzylnitrile (104-47-2) → 1-(2,4,5-trihydroxyphenyl)-2-(4'-methoxyphenyl)ethanone (76095-38-0)

Guidance literature:

1,2,4-Trihydroxybenzene; p-methoxybenzylnitrile; With hydrogenchloride; zinc(II) chloride; In diethyl ether; at 0 - 20 ℃;

With water; In methanol; Reflux;

DOI:10.1016/j.bmc.2009.05.019

Reference yield: 7.0%

4-Methoxyphenylacetic acid (104-01-8) + 1,2,4-Trihydroxybenzene (533-73-3) → 1-(2,4,5-trihydroxyphenyl)-2-(4'-methoxyphenyl)ethanone (76095-38-0)

Guidance literature:

With boron trifluoride diethyl etherate; In N,N-dimethyl-formamide; at 120 ℃; for 0.166667h;

DOI:10.1248/cpb.57.346

Reference yield:

p-methoxybenzylnitrile (104-47-2) → 1-(2,4,5-trihydroxyphenyl)-2-(4'-methoxyphenyl)ethanone (76095-38-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ZnCl₂, HCl gas / diethyl ether / 0 °C / overnight

2: H₂O / 2 h / Heating

With hydrogenchloride; zinc(II) chloride; In diethyl ether; water;

upstream raw materials:

p-methoxybenzylnitrile

1,2,4-Trihydroxybenzene

4-Methoxyphenylacetic acid

Downstream raw materials:

6,7-dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one

α-hydroxymethyl-4-methoxybenzyl 2-hydroxy-4,5-dimethoxyphenyl ketone

6,7,4'-trimethoxyisoflavanone

1-(2-hydroxy-4,5-dimethoxyphenyl)-2-(4-methoxyphenyl)ethanone

Refernces

• 1、 Lu, Tzy-Ming,Kuo, Daih-Huang,Ko, Horng-Huey,Ng, Lean-Teik. "Synthesis and structure-activity relationship study of deoxybenzoins on relaxing effects of porcine coronary artery". experimental part. p. 10027 - 10032. Retrieved 2011/05/17.
• 2、 Goto, Hideyuki,Terao, Yoshiyasu,Akai, Shuji. "Synthesis of various kinds of isoflavones, isoflavanes, and biphenyl- ketones and their 1,1-diphenyl-2-picrylhydrazyl radical-scavenging activities". experimental part. p. 346 - 360. Retrieved 2009/12/27.