p-Isopropylphenylsuccinimide

Base Information

• Chemical Name: p-Isopropylphenylsuccinimide
• CAS No.: 115906-17-7
• Molecular Formula: C₁₃H₁₅NO₂
• Molecular Weight: 217.268
• DSSTox Substance ID: DTXSID70921839
• Mol file: 115906-17-7.mol

Synonyms:p-Isopropylphenylsuccinimide;BRN 5526647;3-(4-(1-Methylethyl)phenyl)-2,5-pyrrolidinedione;2,5-Pyrrolidinedione, 3-(4-(1-methylethyl)phenyl)-;115906-17-7;DTXSID70921839;LS-137697;5-Hydroxy-3-[4-(propan-2-yl)phenyl]-3,4-dihydro-2H-pyrrol-2-one

Chemical Property of p-Isopropylphenylsuccinimide

Chemical Property:

• Vapor Pressure: 1.59E-06mmHg at 25°C
• Boiling Point: 397.4°Cat760mmHg
• Flash Point: 163.9°C
• Density: 1.131g/cm³
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 217.110278721
• Heavy Atom Count: 16
• Complexity: 290

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C1=CC=C(C=C1)C2CC(=O)NC2=O

Technology Process of p-Isopropylphenylsuccinimide

There total 4 articles about p-Isopropylphenylsuccinimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-isopropylbenzaldehyde) (122-03-2) → p-Isopropylphenylsuccinimide (115906-17-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / piperidine, glacial acetic acid / benzene / 12 h / Heating

2: 2.) aq. NaOH / 1.) aq. EtOH, reflux, 12 h, 2.) reflux, 14 h

3: acetic anhydride / 3 h / Heating

With piperidine; sodium hydroxide; acetic anhydride; acetic acid; In benzene;

DOI:10.1007/BF00768251

Reference yield:

p-Isopropylphenylsuccinic acid (34177-40-7) → p-Isopropylphenylsuccinimide (115906-17-7)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic anhydride / 3 h / Heating

With acetic anhydride;

DOI:10.1007/BF00768251

Reference yield:

Diethyl p-isopropylbenzylidenemalonate (40452-72-0) → p-Isopropylphenylsuccinimide (115906-17-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.) aq. NaOH / 1.) aq. EtOH, reflux, 12 h, 2.) reflux, 14 h

2: acetic anhydride / 3 h / Heating

With sodium hydroxide; acetic anhydride;

DOI:10.1007/BF00768251

upstream raw materials:

(4-isopropyl-phenyl)-succinic acid anhydride

p-Isopropylphenylsuccinic acid

Diethyl p-isopropylbenzylidenemalonate

(4-isopropylbenzaldehyde)

Refernces