D17 Prostaglandin E1

Base Information

Chemical Name:D17 Prostaglandin E1
CAS No.:7046-45-9
Molecular Formula:C20H32O5
Molecular Weight:352.47
Hs Code.:
Nikkaji Number:J562.735D
Metabolomics Workbench ID:2485

Synonyms:17,18-dehydro-PGE1;17,18-dehydroprostaglandin E1;5,6-dihydro-PGE3;5,6-dihydroprostaglandin E3

Suppliers and Price of D17 Prostaglandin E1

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
delta17-ProstaglandinE1
2.5mg
$ 145.00

Total 1 raw suppliers

Chemical Property of D17 Prostaglandin E1

Chemical Property:

PSA：94.83000
LogP:3.25110
XLogP3:2.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:12
Exact Mass:352.22497412
Heavy Atom Count:25
Complexity:469

Purity/Quality:

98%Min ^*data from raw suppliers

delta17-ProstaglandinE1 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC=CCC(C=CC1C(CC(=O)C1CCCCCCC(=O)O)O)O
Isomeric SMILES:CC/C=C\C[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1CCCCCCC(=O)O)O)O

Technology Process of D17 Prostaglandin E1

There total 6 articles about D17 Prostaglandin E1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 127269-01-6
7-{(1R,2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(1E,5Z)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-octa-1,5-dienyl]-5-oxo-cyclopentyl}-heptanoic acid

: 7046-45-9
7-[(1R,2R,3R)-3-Hydroxy-2-((1E,5Z)-(S)-3-hydroxy-octa-1,5-dienyl)-5-oxo-cyclopentyl]-heptanoic acid

Guidance literature:: With hydrogen fluoride; In acetonitrile; for 0.666667h; Ambient temperature;
DOI:10.1016/S0040-4039(00)99365-1

Reference yield:

: 117254-07-6
(4R)-2-(N,N-diethylamino)methyl-4-(t-butyldimethylsiloxy)-cyclopent-2-en-1-ol

: 7046-45-9
7-[(1R,2R,3R)-3-Hydroxy-2-((1E,5Z)-(S)-3-hydroxy-octa-1,5-dienyl)-5-oxo-cyclopentyl]-heptanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi, (2-thienyl)Cu(CN)Li / 1.) THF, -78 deg C; 2.) THF, -78 to 0 deg C, 1 h

2: 76 percent / (2-thienyl)Cu(CN)Li / tetrahydrofuran / -78 deg C up to 0 deg C

3: 87 percent / PPTS / propan-2-ol; diethyl ether / 5 h / Ambient temperature

4: 91 percent / Jones reagent / acetone; diethyl ether / 0.5 h / 0 °C

5: 89 percent / aq. HF / acetonitrile / 0.67 h / Ambient temperature

With n-butyllithium; jones reagent; hydrogen fluoride; thien-2-yl(cyano)copper lithium; pyridinium p-toluenesulfonate; In tetrahydrofuran; diethyl ether; isopropyl alcohol; acetone; acetonitrile;
DOI:10.1016/S0040-4039(00)99365-1

Reference yield:

: 127268-93-3
tert-Butyl-dimethyl-[(Z)-(S)-1-((E)-2-tributylstannanyl-vinyl)-hex-3-enyloxy]-silane

: 7046-45-9
7-[(1R,2R,3R)-3-Hydroxy-2-((1E,5Z)-(S)-3-hydroxy-octa-1,5-dienyl)-5-oxo-cyclopentyl]-heptanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi, (2-thienyl)Cu(CN)Li / 1.) THF, -78 deg C; 2.) THF, -78 to 0 deg C, 1 h

2: 76 percent / (2-thienyl)Cu(CN)Li / tetrahydrofuran / -78 deg C up to 0 deg C

3: 87 percent / PPTS / propan-2-ol; diethyl ether / 5 h / Ambient temperature

4: 91 percent / Jones reagent / acetone; diethyl ether / 0.5 h / 0 °C

5: 89 percent / aq. HF / acetonitrile / 0.67 h / Ambient temperature

With n-butyllithium; jones reagent; hydrogen fluoride; thien-2-yl(cyano)copper lithium; pyridinium p-toluenesulfonate; In tetrahydrofuran; diethyl ether; isopropyl alcohol; acetone; acetonitrile;
DOI:10.1016/S0040-4039(00)99365-1