Methyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate

Base Information

Chemical Name:Methyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate
CAS No.:84088-51-7
Molecular Formula:C12H10ClNO3
Molecular Weight:251.6657
Hs Code.:
DSSTox Substance ID:DTXSID50379758
Wikidata:Q82169714

Synonyms:84088-51-7;methyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate;Methyl 4-chloro-1,2-dihydro-1-methyl-2-oxoquinoline-3-carboxylate;SCHEMBL10672326;DTXSID50379758

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate

Chemical Property:

Vapor Pressure:6.39E-05mmHg at 25°C
Boiling Point:344.9°Cat760mmHg
Flash Point:162.4°C
PSA：48.30000
Density:1.39g/cm³
LogP:1.97850
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:251.0349209
Heavy Atom Count:17
Complexity:391

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1C2=CC=CC=C2C(=C(C1=O)C(=O)OC)Cl

Technology Process of Methyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate

There total 2 articles about Methyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 84088-50-6
4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid methyl ester

: 84088-51-7
1,2-dihydro-4-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester

Guidance literature:: With triethylamine; trichlorophosphate; at 60 ℃; for 3h;
DOI:10.1002/jhet.5570350322

Reference yield:

: 10328-92-4
N-Methylisatoic anhydride

: 84088-51-7
1,2-dihydro-4-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / NaH / dimethylformamide

2: 93 percent / POCl₃, Et₃N / 3 h / 60 °C

With sodium hydride; triethylamine; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570350322

Reference yield:

: 4-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid

: 79966-24-8
1,2-dihydro-4-methoxy-1-methyl-2-oxo-3-quinolinecarboxylic acid methyl ester

: 84088-51-7
1,2-dihydro-4-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester

: N-phenyl-1,2-dihydro-4-methoxy-1-methyl-2-oxo-quinoline-3-carboxamide

Guidance literature:: With sodium hydroxide; thionyl chloride; sodium methylate; triethylamine; aniline; In 1,4-dioxane; methanol; dichloromethane; chloroform; water;