diethyl ({[2-(1H-pyrrol-1-yl)phenyl]amino}methylidene)propanedioate

Base Information

• Chemical Name: diethyl ({[2-(1H-pyrrol-1-yl)phenyl]amino}methylidene)propanedioate
• CAS No.: 58785-18-5
• Molecular Formula: C₁₈H₂₀N₂O₄
• Molecular Weight: 328.368
• Mol file: 58785-18-5.mol

Synonyms:Propanedioicacid, [[[2-(1H-pyrrol-1-yl)phenyl]amino]methylene]-, diethyl ester (9CI); NSC338542

Chemical Property of diethyl ({[2-(1H-pyrrol-1-yl)phenyl]amino}methylidene)propanedioate

Chemical Property:

• Vapor Pressure: 1.82E-07mmHg at 25°C
• Boiling Point: 426.1°Cat760mmHg
• Flash Point: 211.5°C
• Density: 1.14g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diethyl ({[2-(1H-pyrrol-1-yl)phenyl]amino}methylidene)propanedioate

There total 2 articles about diethyl ({[2-(1H-pyrrol-1-yl)phenyl]amino}methylidene)propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.3%

2-(1H-pyrrol-1-yl)aniline (6025-60-1) + diethyl 2-ethoxymethylenemalonate (87-13-8) → diethyl 2-(1-pyrrolyl)anilinomethylenemalonate (58785-18-5)

Guidance literature:

at 120 ℃; for 0.5h;

Reference yield:

→ diethyl 2-(1-pyrrolyl)anilinomethylenemalonate (58785-18-5)

Guidance literature:

11, Diethyl-ethoxymethylenmalonat;

Reference yield:

diethyl 2-(1-pyrrolyl)anilinomethylenemalonate (58785-18-5) → piroxacin (93906-65-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 84.6 percent / diphenyl ether / 30 h / Heating

2: 10percent sodium hydroxide / H₂O / 1 h / Heating

3: 75 percent / dimethylformamide / 4 h / 80 °C

4: 55.6 percent / 10percent sodium hydroxide / H₂O / 1 h / Heating

With sodium hydroxide; In diphenylether; water; N,N-dimethyl-formamide;

upstream raw materials:

2-(1H-pyrrol-1-yl)aniline

diethyl 2-ethoxymethylenemalonate

Downstream raw materials:

piroxacin

Refernces