N-[(20S)-20-(Dimethylamino)-4,4,14-trimethyl-9,19-cyclo-5α-pregnan-3β-yl]-N-methylacetamide

Base Information

• Chemical Name: N-[(20S)-20-(Dimethylamino)-4,4,14-trimethyl-9,19-cyclo-5α-pregnan-3β-yl]-N-methylacetamide
• CAS No.: 16975-11-4
• Molecular Formula: C₂₉H₅₀N₂O
• Molecular Weight: 442.729
• Mol file: 16975-11-4.mol

Synonyms:Acetamide,N-[20a-(dimethylamino)-4,4,14-trimethyl-9,19-cyclo-5a,9b-pregnan-3b-yl]-N-methyl- (8CI); 1H,19H-Cyclopropa[9,10]cyclopenta[a]phenanthrene,acetamide deriv.; 9,19-Cyclopregnane, acetamide deriv.; Buxaline C;N-Acetylcycloprotobuxine C

Chemical Property of N-[(20S)-20-(Dimethylamino)-4,4,14-trimethyl-9,19-cyclo-5α-pregnan-3β-yl]-N-methylacetamide

Chemical Property:

• PSA: 23.55000
• LogP: 6.22250

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: One of the numerous Buxus alkaloids, buxaline C occurs in B. sernpervirens. It forms colourless needles from Et20 and has the structure shown above which is based upon infrared, NMR and mass spectrometry and comparison with the cyc1oprotobuxines.

Technology Process of N-[(20S)-20-(Dimethylamino)-4,4,14-trimethyl-9,19-cyclo-5α-pregnan-3β-yl]-N-methylacetamide

There total 3 articles about N-[(20S)-20-(Dimethylamino)-4,4,14-trimethyl-9,19-cyclo-5α-pregnan-3β-yl]-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzoylcycloprotobuxine-C → N-Acetyl-cycloprotobuxin-C (16975-11-4)

Guidance literature:

Multi-step reaction with 2 steps

1: base hydrolysis

2: pyridine

With pyridine;

DOI:10.1023/A:1024188831456

Reference yield:

cycloprotobuxine-C (1936-70-5) + acetic anhydride (108-24-7) → N-Acetyl-cycloprotobuxin-C (16975-11-4)

Guidance literature:

With pyridine;

DOI:10.1023/A:1024188831456

Reference yield:

→ N-Acetyl-cycloprotobuxin-C (16975-11-4)

Guidance literature:

Cycloprotobuxin-C, Acetylchlorid;

DOI:10.1016/S0040-4020(01)92557-8

upstream raw materials:

cycloprotobuxine-C

acetic anhydride

Refernces