n-Butylpiperidine-1-carboxamide

Base Information

• Chemical Name: n-Butylpiperidine-1-carboxamide
• CAS No.: 1461-79-6
• Molecular Formula: C10H20 N2 O
• Molecular Weight: 184.282
• NSC Number: 84335
• DSSTox Substance ID: DTXSID20292647
• Nikkaji Number: J2.430.024B
• Wikidata: Q82031038
• Mol file: 1461-79-6.mol

Synonyms:n-butylpiperidine-1-carboxamide;1461-79-6;1-Piperidinecarboxamide, N-butyl-;NSC84335;F3233-0005;SCHEMBL1681188;DTXSID20292647;HMS1605F03;CCG-40482;NSC-84335;AKOS002250113;VU0606212-1;5076-23-3

Chemical Property of n-Butylpiperidine-1-carboxamide

Chemical Property:

• Vapor Pressure: 4.38E-05mmHg at 25°C
• Boiling Point: 350.5°Cat760mmHg
• Flash Point: 165.8°C
• Density: 0.984g/cm³
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 184.157563266
• Heavy Atom Count: 13
• Complexity: 153

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCNC(=O)N1CCCCC1

Technology Process of n-Butylpiperidine-1-carboxamide

There total 7 articles about n-Butylpiperidine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

piperidine (110-89-4) + S-methyl N-butylthiocarbamate (39078-72-3) → N-butylpiperidine-1-carboxamide (1461-79-6)

Guidance literature:

In acetonitrile; at 30 ℃; for 6h;

DOI:10.1016/S0040-4039(98)00561-9

Reference yield: 81.0%

piperidine (110-89-4) + n-butyl isocyanide (111-36-4) → N-butylpiperidine-1-carboxamide (1461-79-6)

Guidance literature:

In dichloromethane; at -10 - 20 ℃; Inert atmosphere;

DOI:10.3390/molecules22101688

Reference yield: 72.0%

2,2,2-trichloroethyl piperidine-1-carboxylate + N-butylamine (109-73-9,85404-21-3) → N-butylpiperidine-1-carboxamide (1461-79-6)

Guidance literature:

With calcium iodide; In toluene; at 80 ℃; for 12h;

DOI:10.1039/c9nj03111a

upstream raw materials:

piperidine

S-methyl N-butylthiocarbamate

n-butyl isocyanide

n-butyl isonitrile