methyl N-(tert-butoxycarbonyl)tryptophylhistidinate

Base Information

Chemical Name:methyl N-(tert-butoxycarbonyl)tryptophylhistidinate
CAS No.:72156-59-3
Molecular Formula:C23H29N5O5
Molecular Weight:455.514
Hs Code.:

Synonyms:

Suppliers and Price of methyl N-(tert-butoxycarbonyl)tryptophylhistidinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of methyl N-(tert-butoxycarbonyl)tryptophylhistidinate

Chemical Property:

Vapor Pressure:1.68E-24mmHg at 25°C
Boiling Point:783.5°Cat760mmHg
Flash Point:427.6°C
Density:1.284g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of methyl N-(tert-butoxycarbonyl)tryptophylhistidinate

There total 9 articles about methyl N-(tert-butoxycarbonyl)tryptophylhistidinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 13139-14-5
Boc-Trp-OH

: 4467-54-3,5619-10-3,7389-87-9,18684-16-7,22888-60-4,32381-17-2,92742-29-5,100009-20-9
l-histidine methyl ester dihydrochloride

: 72156-59-3
N-α-Boc-L-Trp-L-His-OMe

Guidance literature:: With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In water; at 60 ℃; for 0.5h; under 2068.65 Torr;
DOI:10.1016/j.bmcl.2014.04.120

Reference yield: 67.0%

: 13139-14-5
Boc-Trp-OH

: 1499-46-3
L-Histidine methyl ester

: 72156-59-3
N-α-Boc-L-Trp-L-His-OMe

Guidance literature:: Boc-Trp-OH; With endo-N-hydroxy-5-norbornene-2,3-dicarboximide; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at -10 ℃; for 0.0833333h;

L-Histidine methyl ester; In N,N-dimethyl-formamide; at 4 ℃; for 36h;
DOI:10.1021/jm900622d

Reference yield:

: 17791-52-5
N-(tert-butoxycarbonyl)-L-histidine

: 72156-59-3
N-α-Boc-L-Trp-L-His-OMe

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 14 h / 20 °C

2: diisopropyl-carbodiimide; endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 60 °C / Microwave irradiation

With hydrogenchloride; endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.7b00481