Technology Process of methyl N-(tert-butoxycarbonyl)tryptophylhistidinate
There total 9 articles about methyl N-(tert-butoxycarbonyl)tryptophylhistidinate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
water;
at 60 ℃;
for 0.5h;
under 2068.65 Torr;
DOI:10.1016/j.bmcl.2014.04.120
- Guidance literature:
-
Boc-Trp-OH;
With
endo-N-hydroxy-5-norbornene-2,3-dicarboximide; diisopropyl-carbodiimide;
In
N,N-dimethyl-formamide;
at -10 ℃;
for 0.0833333h;
L-Histidine methyl ester;
In
N,N-dimethyl-formamide;
at 4 ℃;
for 36h;
DOI:10.1021/jm900622d
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogenchloride / 14 h / 20 °C
2: diisopropyl-carbodiimide; endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 60 °C / Microwave irradiation
With
hydrogenchloride; endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide;
In
N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.7b00481
