Platydesmine

Base Information

Chemical Name:Platydesmine
CAS No.:2824-86-4
Molecular Formula:C₁₅H₁₇NO₃
Molecular Weight:259.305
Hs Code.:
DSSTox Substance ID:DTXSID40182495
Nikkaji Number:J15.148C
Wikidata:Q27149723
Mol file:2824-86-4.mol

Synonyms:Platydesmine;2824-86-4;Furo(2,3-b)quinoline-2-methanol, 2,3-dihydro-4-methoxy-alpha,alpha-dimethyl-, (R)-;(+)-Platydesmine;CHEBI:80682;DTXSID40182495;2-[(2R)-4-methoxy-2,3-dihydrofuro[2,3-b]quinolin-2-yl]propan-2-ol;Q27149723;Furo[2,3-b]quinoline-2-methanol, 2,3-dihydro-4-methoxy-.alpha.,.alpha.-dimethyl-, (2R)-

Suppliers and Price of Platydesmine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Platydesmine

Chemical Property:

Vapor Pressure:1.84E-07mmHg at 25°C
Melting Point:137-8°C
Boiling Point:410.1°Cat760mmHg
Flash Point:201.8°C
PSA：51.58000
Density:1.245g/cm³
LogP:2.31780
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:259.12084340
Heavy Atom Count:19
Complexity:333

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C1CC2=C(C3=CC=CC=C3N=C2O1)OC)O
Isomeric SMILES:CC(C)([C@H]1CC2=C(C3=CC=CC=C3N=C2O1)OC)O
Description This furoquinoline alkaloid was first isolated from Platydesma campanulata Mann and subsequently found in Geijera salicifolia Schott. It crystallizes from C6H6-light petroleum in white needles and has [α]25D + 43° (CHCl3). The ultraviolet spectrum in EtOH contains several absorption maxima at 229.3, 238.1, 253.5,262.3,272,283,307.2 and 320.5 mJ.l. with a shoulder at 294.5 mil. The methiodide forms colourless plates from EtOH, m.p. 1 62-4°C and the picrate has m.p. 107-9°C after softening at 93°C. The optically inactive base, obtained as prisms from a mixture of MeOH and isopropyl ether, melts at 137 -SoC and gives a picrate melting over a very wide temperature range from 96-l22°C.

Technology Process of Platydesmine

There total 4 articles about Platydesmine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 316172-96-0
(+)-(R)-4-methoxy-3-(2'-acetoxy-3'-bromo-3'-methylbutyl)quinolin-2(1H)-one

: 2824-86-4
(+)-(S)-platydesmine

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1039/b005285j

Reference yield:

: 7282-19-1
atanine

: 2824-86-4,7764-73-0,97320-72-4
(+)-platydesmine

Guidance literature:: With peroxylaurinoic acid; In chloroform; at 25 ℃; for 120h;
DOI:10.1039/j39660001504

Reference yield:

: 7282-19-1
atanine

: 2824-86-4
(+)-(S)-platydesmine

Guidance literature:: Multi-step reaction with 3 steps

1: AD-mix-β; methanesulfonamide / 2-methyl-propan-2-ol; H2O / 24 h / 0 °C

2: 85 percent / acetonitrile / 0 °C

3: 67 percent / t-BuOK / tetrahydrofuran / 3 h / 20 °C

With methanesulfonamide; AD-mix-β; potassium tert-butylate; In tetrahydrofuran; water; acetonitrile; tert-butyl alcohol; 1: Addition / 2: Acetylation / 3: Cyclization;
DOI:10.1039/b005285j