6-methoxy-2-nitronaphtho(1,8-bc)pyran

Base Information

• Chemical Name: 6-methoxy-2-nitronaphtho(1,8-bc)pyran
• CAS No.: 105052-39-9
• Molecular Formula: C₁₃H₉NO₄
• Molecular Weight: 243.219
• Hs Code.: 2909309090
• Mol file: 105052-39-9.mol

Synonyms:R 7779

Chemical Property of 6-methoxy-2-nitronaphtho(1,8-bc)pyran

Chemical Property:

• Vapor Pressure: 2.01E-06mmHg at 25°C
• Boiling Point: 405.8°Cat760mmHg
• Flash Point: 191.4°C
• PSA: 64.28000
• Density: 1.41g/cm³
• LogP: 3.33910

Purity/Quality:

6-METHOXY-2-NITRONAPHTHO(1,8-BC)PYRAN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-methoxy-2-nitronaphtho(1,8-bc)pyran

There total 3 articles about 6-methoxy-2-nitronaphtho(1,8-bc)pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,5-dimethoxynaphthalene (10075-63-5) → methoxy-6 nitro-2 naphto<1,8-bc>pyranne (105052-39-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / POCl₃ / toluene

2: 81 percent / BBr₃ / CH₂Cl₂ / -70 °C

3: 1) K₂CO₃, 2) Ac₂O / 1) acetone, 4 h then RT, overnight, 2) reflux, 1 h

With acetic anhydride; boron tribromide; potassium carbonate; trichlorophosphate; In dichloromethane; toluene;

Reference yield:

4,8-dimethoxy-1-naphthaldehyde (69833-11-0) → methoxy-6 nitro-2 naphto<1,8-bc>pyranne (105052-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / BBr₃ / CH₂Cl₂ / -70 °C

2: 1) K₂CO₃, 2) Ac₂O / 1) acetone, 4 h then RT, overnight, 2) reflux, 1 h

With acetic anhydride; boron tribromide; potassium carbonate; In dichloromethane;

Reference yield:

bromonitromethane (563-70-2) + 5-hydroxy-1-methoxy-4-naphthalenecarboxaldehyde (67243-03-2) → methoxy-6 nitro-2 naphto<1,8-bc>pyranne (105052-39-9)

Guidance literature:

With acetic anhydride; potassium carbonate; Yield given. Multistep reaction; 1) acetone, 4 h then RT, overnight, 2) reflux, 1 h;

upstream raw materials:

bromonitromethane

5-hydroxy-1-methoxy-4-naphthalenecarboxaldehyde

1,5-dimethoxynaphthalene

4,8-dimethoxy-1-naphthaldehyde

Refernces

• 1、 Royer,Buisson,Vleminckx,Moens. "About new highly genotoxic agents: Oxaphenalene nitro derivatives". . p. 351 - 354. Retrieved 2007/10/02.