2-Methylimidazo[1,2-a]pyridine-3-carbohydrazide

Base Information

• Chemical Name: 2-Methylimidazo[1,2-a]pyridine-3-carbohydrazide
• CAS No.: 144835-67-6
• Molecular Formula: C9H10 N4 O
• Molecular Weight: 190.205
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID40351467
• Wikidata: Q82127903
• ChEMBL ID: CHEMBL1581499
• Mol file: 144835-67-6.mol

Synonyms:144835-67-6;2-methylimidazo[1,2-a]pyridine-3-carbohydrazide;2-Methyl-imidazo[1,2-a]pyridine-3-carboxylic acid hydrazide;MLS000375438;Oprea1_761527;SCHEMBL4343195;CHEMBL1581499;DTXSID40351467;HMS2564E17;2-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLICACIDHYDRAZIDE;MFCD00269303;STL411830;AKOS000116191;PS-6222;SB85971;SMR000254692;CS-0211651;EN300-03645;F83047;AG-996/30948035;Z56922136;imidazo[1,2-a]pyridine-3-carboxylic acid,2-methyl-,hydrazide

Chemical Property of 2-Methylimidazo[1,2-a]pyridine-3-carbohydrazide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 75.91000
• Density: 1.42g/cm³
• LogP: 1.52130
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 190.08546096
• Heavy Atom Count: 14
• Complexity: 233

Purity/Quality:

98%Min ^*data from raw suppliers

2-Methylimidazo[1,2-a]pyridine-3-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N2C=CC=CC2=N1)C(=O)NN

Technology Process of 2-Methylimidazo[1,2-a]pyridine-3-carbohydrazide

There total 3 articles about 2-Methylimidazo[1,2-a]pyridine-3-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethyl 2-methylimidazo[1,2-a]pyridine-3-carboxylate (2549-19-1) → 2-methyl-4H-imidazo[1,2-a]pyridine-3-carbohydrazide (144835-67-6)

Guidance literature:

With hydrazine hydrate; In ethanol; water; for 3h; Reflux;

DOI:10.1016/j.bmc.2014.05.038

Reference yield:

2-aminopyridine (504-29-0) → 2-methyl-4H-imidazo[1,2-a]pyridine-3-carbohydrazide (144835-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / ethanol / 20 h / Heating

2: 70 percent / 80percent N₂H₄*H₂O / ethanol / 20 h / Heating

With hydrazine hydrate; In ethanol;

DOI:10.1016/S0223-5234(98)80012-3

Reference yield:

2-aminopyridine (504-29-0) → 2-methyl-4H-imidazo[1,2-a]pyridine-3-carbohydrazide (144835-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 20 h / Reflux

2: hydrazine hydrate / ethanol / 3 h / 70 °C

With hydrazine hydrate; In ethanol;

DOI:10.1021/jm300514y

upstream raw materials:

ethyl 2-methylimidazo[1,2-a]pyridine-3-carboxylate

2-aminopyridine

Downstream raw materials:

2-methyl-N'-(4-methylbenzylidene)imidazo[1,2-a]pyridine-3-carbohydrazide

C₁₆H₁₅N₅OS

C₁₃H₁₅N₅OS