2-(S-methylsulfonimidoyl)aniline

Base Information

• Chemical Name: 2-(S-methylsulfonimidoyl)aniline
• CAS No.: 67483-70-9
• Molecular Formula: C7H10N2OS
• Molecular Weight: 170.2321
• Mol file: 67483-70-9.mol

Synonyms:

Chemical Property of 2-(S-methylsulfonimidoyl)aniline

Chemical Property:

• Vapor Pressure: 0.000784mmHg at 25°C
• Boiling Point: 306.2°Cat760mmHg
• Flash Point: 139°C
• Density: 1.28g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(S-methylsulfonimidoyl)aniline

There total 4 articles about 2-(S-methylsulfonimidoyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

S-[2-(tert-butoxycarbonyl)aminophenyl]-S-methylsulfoximine → S-(2-aminophenyl)-S-methylsulfoximine (67483-70-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1002/chem.201602550

Reference yield: 51.0%

(2-bromophenyl)(imino)(methyl)-λ6-sulfanone (833459-47-5) → S-(2-aminophenyl)-S-methylsulfoximine (67483-70-9)

Guidance literature:

With copper(I) oxide; trimethylsilylazide; tetra-(n-butyl)ammonium iodide; In water; at 90 ℃; for 12h; Green chemistry;

DOI:10.1021/acs.joc.9b02828

Reference yield:

N-(2-methylsulfanyl-phenyl)-acetamide (6310-41-4) → S-(2-aminophenyl)-S-methylsulfoximine (67483-70-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.25 - 1.5 h / -30 °C / Cooling with acetonitrile/dry ice

2: sodium azide; sulfuric acid / chloroform / 20 - 40 °C

3: sodium hydroxide; water / 3 h / 120 °C / Heating / reflux

With sodium hydroxide; sodium azide; sulfuric acid; water; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform;

upstream raw materials:

N-(2-methylsulfanyl-phenyl)-acetamide

acetic acid-(2-methanesulfinyl-anilide)

(2-bromophenyl)(imino)(methyl)-λ⁶-sulfanone

Refernces

• 1、 Cheng, Ying,Dong, Wanrong,Wang, Han,Bolm, Carsten. "Rhodium-Catalyzed ortho-Amidations in the Preparation of Thiadiazine 1-Oxides". supporting information. p. 10821 - 10824. Retrieved 2016/07/28.