Santarubin B 3'-methyl ether

Base Information

• Chemical Name: Santarubin B 3'-methyl ether
• CAS No.: 65984-91-0
• Molecular Formula: C35H30O10
• Molecular Weight: 610.61
• Mol file: 65984-91-0.mol

Synonyms:6-(2,4-dimethoxy-benzyl)-2,10-dihydroxy-5-(4-hydroxy-3-methoxy-phenyl)-1,3-dimethoxy-benzo[a]xanthen-9-one;Santarubin A;

Chemical Property of Santarubin B 3'-methyl ether

Chemical Property:

• Melting Point: 287 °C (methanol)
• Boiling Point: 845.3±65.0 °C(Predicted)
• PKA: 7.26±0.20(Predicted)
• PSA: 137.05000
• Density: 1.47±0.1 g/cm3(Predicted)
• LogP: 6.46860

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Santarubin B 3'-methyl ether

There total 7 articles about Santarubin B 3'-methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(E)-tert-butyl(4-(3-(2,4-dimethoxyphenyl)prop-1-en-1-yl)-2-methoxyphenoxy)dimethylsilane + 6-hydroxy-3-(3-hydroxy-2,4-dimethoxyphenyl)-7H-chromen-7-one → santarubin A (65984-91-0)

Guidance literature:

With air; In methanol; acetonitrile; at 80 ℃; for 9h;

DOI:10.1002/anie.201302317

Reference yield:

3-bromo-2,6-dimethoxyphenol (18111-34-7) → santarubin A (65984-91-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C / Inert atmosphere

2: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

3: diisobutylaluminium hydride / dichloromethane / 1 h / -78 °C / Inert atmosphere

4: perchloric acid / acetic acid; water / 9 h / 20 °C / Inert atmosphere

5: 2,6-di-tert-butyl-pyridine / acetonitrile / 1.17 h / Inert atmosphere

6: air / methanol; acetonitrile / 9 h / 80 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 1H-imidazole; dmap; perchloric acid; 2,6-di-tert-butyl-pyridine; palladium diacetate; diisobutylaluminium hydride; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1002/anie.201302317

Reference yield:

6,7-bis((tert-butyldimethylsilyl)oxy)-3-(3'-((tert-butyldimethylsilyl)oxy)-2,4-dimethoxyphenyl)-2H-chromen-2-ol → santarubin A (65984-91-0)

Guidance literature:

Multi-step reaction with 3 steps

1: perchloric acid / acetic acid; water / 9 h / 20 °C / Inert atmosphere

2: 2,6-di-tert-butyl-pyridine / acetonitrile / 1.17 h / Inert atmosphere

3: air / methanol; acetonitrile / 9 h / 80 °C

With perchloric acid; 2,6-di-tert-butyl-pyridine; In methanol; water; acetic acid; acetonitrile;

DOI:10.1002/anie.201302317

upstream raw materials:

3-bromo-2,6-dimethoxyphenol

1,3-dimethoxy-2-hydroxy-benzene

Refernces