PARECOXIB SODIUM

Base Information

• Chemical Name: PARECOXIB SODIUM
• CAS No.: 198470-85-8
• Molecular Formula: C19H18N2O4S. Na
• Molecular Weight: 392.404
• Mol file: 198470-85-8.mol

Synonyms:Propanamide,N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-, sodium salt (9CI);Parecoxib sodium;Rayzon;SC 69124A;

Chemical Property of PARECOXIB SODIUM

Chemical Property:

• Melting Point: 273-275°C
• Boiling Point: 538°Cat760mmHg
• Flash Point: 279.2°C
• PSA: 85.62000
• LogP: 5.39680
• Storage Temp.: Refrigerator
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 393.08849752
• Heavy Atom Count: 27
• Complexity: 575

Purity/Quality:

99% up by HPLC ^*data from raw suppliers

ParecoxibSodium ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C.[Na]
• Description: Parecoxib is a prodrug form of the COX-2 inhibitor valdecoxib . It is converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys. Parecoxib is also a cannabinoid (CB) receptor 1 agonist with an EC50 value of 2.4 μM in HEK293 cells. It reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg).
• Uses: Anti-inflammatory, analgesic.