(-)-5-m-hydroxyphenyl-2-methylmorphan

Base Information

Chemical Name:(-)-5-m-hydroxyphenyl-2-methylmorphan
CAS No.:28623-84-9
Molecular Formula:C₁₅H₂₁NO
Molecular Weight:231.338
Hs Code.:2933990090
Mol file:28623-84-9.mol

Synonyms:Phenol,3-(2-methyl-2-azabicyclo[3.3.1]non-5-yl)-, (1R)-; Phenol,m-(2-methyl-2-azabicyclo[3.3.1]non-5-yl)-, (-)- (8CI);2-Azabicyclo[3.3.1]nonane, phenol deriv.; NIH 8508

Suppliers and Price of (-)-5-m-hydroxyphenyl-2-methylmorphan

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(-)-5-M-HYDROXYPHENYL-2-METHYLMORPHAN 95.00%
5MG
$ 495.48

Total 4 raw suppliers

Chemical Property of (-)-5-m-hydroxyphenyl-2-methylmorphan

Chemical Property:

Vapor Pressure:9.73E-06mmHg at 25°C
Boiling Point:361.8°Cat760mmHg
Flash Point:173.7°C
PSA：23.47000
Density:1.106g/cm³
LogP:2.84600

Purity/Quality:

99% ^*data from raw suppliers

(-)-5-M-HYDROXYPHENYL-2-METHYLMORPHAN 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (-)-5-m-hydroxyphenyl-2-methylmorphan

There total 10 articles about (-)-5-m-hydroxyphenyl-2-methylmorphan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 28623-84-9
(-)-(1R,5S)-5-(3-hydroxyphenyl)-2-methyl-2-azabicyclo<3.3.1>nonane

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-BuLi / tetrahydrofuran / 2 h / -60 °C

1.2: tetrahydrofuran / 2 h / 20 °C

2.1: 51.4 g / p-toluenesulfonic acid monohydrate / toluene / 6 h / Heating

3.1: sec-BuLi / cyclohexane; tetrahydrofuran / 1 h / -40 °C

3.2: cyclohexane; tetrahydrofuran / 2 h / 0 °C

4.1: aq. H₃PO₄; formic acid / 72 h / 20 °C

5.1: 35.2 g / NaBH₄ / methanol / 2 h / 20 °C

6.1: (+)-di-O,O'-p-toluyl-D-tartaric acid / acetone / 0.33 h

6.2: NH₄OH

7.1: 93 percent / hydrogen / Pd/C / methanol / 6 h / 20 °C / 3102.97 Torr

8.1: hydrogen / Pd/C

9.1: aq. HBr

With sodium tetrahydroborate; n-butyllithium; (2S,3S)-di-4-toluoyltartaric acid; hydrogen bromide; hydrogen; sec.-butyllithium; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; formic acid; cyclohexane; phosphoric acid; acetone; toluene;
DOI:10.1039/b618875c

Reference yield:

: 2398-37-0
3-methoxyphenyl bromide

: 28623-84-9
(-)-(1R,5S)-5-(3-hydroxyphenyl)-2-methyl-2-azabicyclo<3.3.1>nonane

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-BuLi / tetrahydrofuran / 2 h / -60 °C

1.2: tetrahydrofuran / 2 h / 20 °C

2.1: 51.4 g / p-toluenesulfonic acid monohydrate / toluene / 6 h / Heating

3.1: sec-BuLi / cyclohexane; tetrahydrofuran / 1 h / -40 °C

3.2: cyclohexane; tetrahydrofuran / 2 h / 0 °C

4.1: aq. H₃PO₄; formic acid / 72 h / 20 °C

5.1: 35.2 g / NaBH₄ / methanol / 2 h / 20 °C

6.1: (+)-di-O,O'-p-toluyl-D-tartaric acid / acetone / 0.33 h

6.2: NH₄OH

7.1: 93 percent / hydrogen / Pd/C / methanol / 6 h / 20 °C / 3102.97 Torr

8.1: hydrogen / Pd/C

9.1: aq. HBr

With sodium tetrahydroborate; n-butyllithium; (2S,3S)-di-4-toluoyltartaric acid; hydrogen bromide; hydrogen; sec.-butyllithium; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; formic acid; cyclohexane; phosphoric acid; acetone; toluene;
DOI:10.1039/b618875c

Reference yield:

: C₂₂H₂₅NO

: 28623-84-9
(-)-(1R,5S)-5-(3-hydroxyphenyl)-2-methyl-2-azabicyclo<3.3.1>nonane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 35.2 g / NaBH₄ / methanol / 2 h / 20 °C

2.1: (+)-di-O,O'-p-toluyl-D-tartaric acid / acetone / 0.33 h

2.2: NH₄OH

3.1: 93 percent / hydrogen / Pd/C / methanol / 6 h / 20 °C / 3102.97 Torr

4.1: hydrogen / Pd/C

5.1: aq. HBr

With sodium tetrahydroborate; (2S,3S)-di-4-toluoyltartaric acid; hydrogen bromide; hydrogen; palladium on activated charcoal; In methanol; acetone;
DOI:10.1039/b618875c