1-(4-Fluorophenyl)-4-(2-hydroxyspiro(benzofuran-3(2H),4'-piperidin)-1'-yl)-1-butanone

Base Information

Chemical Name:1-(4-Fluorophenyl)-4-(2-hydroxyspiro(benzofuran-3(2H),4'-piperidin)-1'-yl)-1-butanone
CAS No.:73962-20-6
Molecular Formula:C22H25ClFNO3
Molecular Weight:405.8902
Hs Code.:
DSSTox Substance ID:DTXSID10995190

Synonyms:BRN 5630043;73962-20-6;1-(4-Fluorophenyl)-4-(2-hydroxyspiro(benzofuran-3(2H),4'-piperidin)-1'-yl)-1-butanone;1-Butanone, 1-(4-fluorophenyl)-4-(2-hydroxyspiro(benzofuran-3(2H),4'-piperidin)-1'-yl)-;C22H24FNO3;DTXSID10995190;1-(4-Fluorophenyl)-4-(2-hydroxy-2H-spiro[1-benzofuran-3,4'-piperidin]-1'-yl)butan-1-one--hydrogen chloride (1/1)

Suppliers and Price of 1-(4-Fluorophenyl)-4-(2-hydroxyspiro(benzofuran-3(2H),4'-piperidin)-1'-yl)-1-butanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-(4-Fluorophenyl)-4-(2-hydroxyspiro(benzofuran-3(2H),4'-piperidin)-1'-yl)-1-butanone

Chemical Property:

Boiling Point:556.9°Cat760mmHg
Flash Point:290.6°C
Density:g/cm³
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:405.1506995
Heavy Atom Count:28
Complexity:512

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC12C(OC3=CC=CC=C23)O)CCCC(=O)C4=CC=C(C=C4)F.Cl

Technology Process of 1-(4-Fluorophenyl)-4-(2-hydroxyspiro(benzofuran-3(2H),4'-piperidin)-1'-yl)-1-butanone

There total 5 articles about 1-(4-Fluorophenyl)-4-(2-hydroxyspiro(benzofuran-3(2H),4'-piperidin)-1'-yl)-1-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 73962-21-7
C₂₃H₂₆FNO₃

: 73962-20-6
C₂₂H₂₄FNO₃

Guidance literature:: With water; hydrogen cation;

Reference yield:

: 73406-68-5
1'-benzyl-spiro[benzofuran-3,4'-piperidin]-2-one

: 73962-20-6
C₂₂H₂₄FNO₃

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) DIBAH; 2.) H₂O

2: Et₃N

3: H₂ / Pd / ethanol / Ambient temperature

4: Na₂CO₃, KI / toluene

5: 80 percent / H₂O / H⁽¹⁺⁾

With water; hydrogen; diisobutylaluminium hydride; sodium carbonate; triethylamine; potassium iodide; hydrogen cation; palladium; In ethanol; toluene;

Reference yield:

: 343811-57-4
C₁₉H₂₁NO₂

: 73962-20-6
C₂₂H₂₄FNO₃

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N

2: H₂ / Pd / ethanol / Ambient temperature

3: Na₂CO₃, KI / toluene

4: 80 percent / H₂O / H⁽¹⁺⁾

With water; hydrogen; sodium carbonate; triethylamine; potassium iodide; hydrogen cation; palladium; In ethanol; toluene;