7-chloro-3-methyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one

Base Information

Chemical Name:7-chloro-3-methyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one
CAS No.:162931-17-1
Molecular Formula:C₁₀H₁₁ClN₂O
Molecular Weight:210.663
Hs Code.:
Mol file:162931-17-1.mol

Synonyms:2H-1,4-Benzodiazepin-2-one,7-chloro-1,3,4,5-tetrahydro-3-methyl-, (?à)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-chloro-3-methyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one

Chemical Property:

Vapor Pressure:2.15E-06mmHg at 25°C
Boiling Point:393.3°Cat760mmHg
Flash Point:191.6°C
Density:1.207g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 7-chloro-3-methyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one

There total 5 articles about 7-chloro-3-methyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: methyl (5-chloro-2-nitrobenzyl)alaninate

: 162931-17-1
7-chloro-3-methyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2- one

Guidance literature:: With iron; acetic acid; at 110 ℃; for 0.5h;

Reference yield:

: 162931-16-0
ethyl N-<(5-chloro-2-nitrophenyl)methyl>alanine

: 162931-17-1
7-chloro-3-methyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2- one

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / PtO₂ / ethanol

2: HOBt / toluene / Heating

With hydrogen; benzotriazol-1-ol; platinum(IV) oxide; In ethanol; toluene; 1: Reduction / 2: Cyclization;
DOI:10.1016/S0968-0896(99)00198-4

Reference yield:

: 67567-44-6
(5-chloro-2-nitrophenyl)-methylamine

: 162931-17-1
7-chloro-3-methyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2- one

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / Na₂CO₃ / dimethylformamide / 1 h / 80 °C

2: H₂ / PtO₂ / ethanol / 3 h / 2223.7 Torr

3: HOBT / toluene / 72 h / Heating

With hydrogen; sodium carbonate; benzotriazol-1-ol; platinum(IV) oxide; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00005a005