2-(2,4-diaminophenyl)acetic acid

Base Information

• Chemical Name: 2-(2,4-diaminophenyl)acetic acid
• CAS No.: 79637-84-6
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 2922499990
• Mol file: 79637-84-6.mol

Synonyms:2,4-diaminophenylacetic acid;

Chemical Property of 2-(2,4-diaminophenyl)acetic acid

Chemical Property:

• Vapor Pressure: 3.35E-08mmHg at 25°C
• Boiling Point: 431.2°Cat760mmHg
• Flash Point: 214.6°C
• PSA: 89.34000
• Density: 1.368g/cm³
• LogP: 1.64050
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(2,4-Diaminophenyl)aceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,4-diaminophenyl)acetic acid

There total 1 articles about 2-(2,4-diaminophenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2,4-dinitro-phenyl)-acetic acid (643-43-6) → 2,4-diaminophenylacetic acid (79637-84-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 4h;

DOI:10.1016/j.bmc.2010.05.021

Reference yield:

2,4-diaminophenylacetic acid (79637-84-6) → N1-(4-fluorophenyl)-N3-(2-oxoindolin-6-yl)malonamide (1474049-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / 6 h / Reflux

2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; acetonitrile / 3 h

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

2,4-diaminophenylacetic acid (79637-84-6) → (Z)-N1-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-N3-(4-fluorophenyl)malonamide (1474049-68-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / water / 6 h / Reflux

2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; acetonitrile / 3 h

3: pyrrolidine / ethanol / 0.33 h / 100 °C / Microwave irradiation

With pyrrolidine; hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

(2,4-dinitro-phenyl)-acetic acid

Downstream raw materials:

N¹-(4-fluorophenyl)-N³-(2-oxoindolin-6-yl)malonamide

(Z)-N¹-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-N³-(4-fluorophenyl)malonamide