1-(2-hydroxy-3-propyl-4-{[4-(2H-tetrazol-5-ylmethyl)phenoxy]methyl}phenyl)ethanone

Base Information

Chemical Name:1-(2-hydroxy-3-propyl-4-{[4-(2H-tetrazol-5-ylmethyl)phenoxy]methyl}phenyl)ethanone
CAS No.:97581-70-9
Molecular Formula:C20H22N4O3
Molecular Weight:366.4137
Hs Code.:

Synonyms:Ethanone,1-(2-hydroxy-3-propyl-4-((4-(1H-tetrazol-5-ylmethyl)phenoxy)methyl)phenyl);5-[4-(4-Acetyl-3-hydroxy-2-propylbenzyloxy)benzyl]-tetrazole;1-(2-Hydroxy-3-propyl-4-((4-(1H-tetrazol-5-ylmethyl)phenoxy)methyl)phenyl)ethanone;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-hydroxy-3-propyl-4-{[4-(2H-tetrazol-5-ylmethyl)phenoxy]methyl}phenyl)ethanone

Chemical Property:

Vapor Pressure:2.31E-15mmHg at 25°C
Boiling Point:607.7°Cat760mmHg
Flash Point:321.3°C
PSA：100.99000
Density:1.259g/cm³
LogP:3.23020

Purity/Quality:

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Technology Process of 1-(2-hydroxy-3-propyl-4-{[4-(2H-tetrazol-5-ylmethyl)phenoxy]methyl}phenyl)ethanone

There total 7 articles about 1-(2-hydroxy-3-propyl-4-{[4-(2H-tetrazol-5-ylmethyl)phenoxy]methyl}phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 97581-58-3
4-(4-Acetyl-3-hydroxy-2-propylbenzyloxy)phenylacetonitrile

: 97581-70-9
1-[2-Hydroxy-3-propyl-4-((4-(1H-tetrazol-5ylmethyl)phenoxy)methyl)phenyl]ethanone

Guidance literature:: With tri-n-butyltin azide; In tetrahydrofuran; for 96h; Heating;
DOI:10.1021/jm00388a028

Reference yield:

: 14191-95-8
4-cyanomethylphenol

: 97581-70-9
1-[2-Hydroxy-3-propyl-4-((4-(1H-tetrazol-5ylmethyl)phenoxy)methyl)phenyl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH, 2.) NaI / 1.) DMF, 1 h, 2.) DMF, RT, 48 h

2: 66 percent / tri-n-butyltin azide / tetrahydrofuran / 96 h / Heating

With tri-n-butyltin azide; sodium hydride; sodium iodide; In tetrahydrofuran;
DOI:10.1021/jm00388a028

Reference yield:

: 97582-36-0
1-<4-(chloromethyl)-2-hydroxy-3-propylphenyl>ethanone

: 97581-70-9
1-[2-Hydroxy-3-propyl-4-((4-(1H-tetrazol-5ylmethyl)phenoxy)methyl)phenyl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH, 2.) NaI / 1.) DMF, 1 h, 2.) DMF, RT, 48 h

2: 66 percent / tri-n-butyltin azide / tetrahydrofuran / 96 h / Heating

With tri-n-butyltin azide; sodium hydride; sodium iodide; In tetrahydrofuran;
DOI:10.1021/jm00388a028