3-Pyrrolidinecarboxylicacid, 4-hydroxy-1-[2-(4-hydroxyphenyl)ethyl]-5-(2-oxooctadecylidene)-2-propyl-,methyl ester, (2S,3S,4R,5E)-

Base Information

Chemical Name:3-Pyrrolidinecarboxylicacid, 4-hydroxy-1-[2-(4-hydroxyphenyl)ethyl]-5-(2-oxooctadecylidene)-2-propyl-,methyl ester, (2S,3S,4R,5E)-
CAS No.:155944-28-8
Molecular Formula:C35H57 N O5
Molecular Weight:571.841
Hs Code.:

Synonyms:3-Pyrrolidinecarboxylicacid, 4-hydroxy-1-[2-(4-hydroxyphenyl)ethyl]-5-(2-oxooctadecylidene)-2-propyl-,methyl ester, (2a,3b,4a,5E)-(-)-; (2S,3S,4R)-Plakoridine A; Plakoridine A

Suppliers and Price of 3-Pyrrolidinecarboxylicacid, 4-hydroxy-1-[2-(4-hydroxyphenyl)ethyl]-5-(2-oxooctadecylidene)-2-propyl-,methyl ester, (2S,3S,4R,5E)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 3-Pyrrolidinecarboxylicacid, 4-hydroxy-1-[2-(4-hydroxyphenyl)ethyl]-5-(2-oxooctadecylidene)-2-propyl-,methyl ester, (2S,3S,4R,5E)-

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Pyrrolidinecarboxylicacid, 4-hydroxy-1-[2-(4-hydroxyphenyl)ethyl]-5-(2-oxooctadecylidene)-2-propyl-,methyl ester, (2S,3S,4R,5E)-

There total 15 articles about 3-Pyrrolidinecarboxylicacid, 4-hydroxy-1-[2-(4-hydroxyphenyl)ethyl]-5-(2-oxooctadecylidene)-2-propyl-,methyl ester, (2S,3S,4R,5E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 267889-01-0
(2S,3S,4R)-1-{2-[4-(tert-Butyl-diphenyl-silanyloxy)-phenyl]-ethyl}-4-hydroxy-5-[2-oxo-octadec-(E)-ylidene]-2-propyl-pyrrolidine-3-carboxylic acid methyl ester

: 155944-28-8
(2S,3S,4R)-plakoridine A

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)00096-4

Reference yield:

: 6547-53-1
2-[4-(benzyloxy)benzyl]acetic acid

: 155944-28-8
(2S,3S,4R)-plakoridine A

Guidance literature:: Multi-step reaction with 13 steps

1.1: DCC; HOBt

2.1: LAH

3.1: 82 percent / n-BuLi

4.1: 51 percent / LDA

5.1: H₂ / Pd/C

5.2: ethyl acetate / reflux

6.1: DMAP

7.1: P₄S₁₀; NaHCO₃

8.1: TsOH / methanol

9.1: Et₃N

10.1: 90 percent / K₂CO₃ / methanol / 0.5 h

11.1: CH₂Cl₂

12.1: PPh₃; Et₃N

13.1: 71 percent / n-Bu₄NF; AcOH / tetrahydrofuran

With dmap; lithium aluminium tetrahydride; n-butyllithium; tetraphosphorus decasulfide; tetrabutyl ammonium fluoride; hydrogen; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; acetic acid; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; 1.1: Acylation / 2.1: Reduction / 3.1: Addition / 4.1: Addition / 4.2: Addition / 5.1: Hydrogenolysis / 5.2: Cyclization / 6.1: silylation / 7.1: sulfuration / 8.1: desilylation / 9.1: silylation / 10.1: Isomerization / 11.1: Alkylation / 12.1: Alkylation / 13.1: desylilation;
DOI:10.1016/S0040-4039(00)00096-4

Reference yield:

: 17138-28-2
(4-hydroxy-phenyl)-acetic acid ethyl ester

: 155944-28-8
(2S,3S,4R)-plakoridine A

Guidance literature:: Multi-step reaction with 15 steps

1.1: K₂CO₃ / dimethylformamide

2.1: NaOH / H₂O; methanol

3.1: DCC; HOBt

4.1: LAH

5.1: 82 percent / n-BuLi

6.1: 51 percent / LDA

7.1: H₂ / Pd/C

7.2: ethyl acetate / reflux

8.1: DMAP

9.1: P₄S₁₀; NaHCO₃

10.1: TsOH / methanol

11.1: Et₃N

12.1: 90 percent / K₂CO₃ / methanol / 0.5 h

13.1: CH₂Cl₂

14.1: PPh₃; Et₃N

15.1: 71 percent / n-Bu₄NF; AcOH / tetrahydrofuran

With dmap; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; tetraphosphorus decasulfide; tetrabutyl ammonium fluoride; hydrogen; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; acetic acid; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Etherification / 2.1: Hydrolysis / 3.1: Acylation / 4.1: Reduction / 5.1: Addition / 6.1: Addition / 6.2: Addition / 7.1: Hydrogenolysis / 7.2: Cyclization / 8.1: silylation / 9.1: sulfuration / 10.1: desilylation / 11.1: silylation / 12.1: Isomerization / 13.1: Alkylation / 14.1: Alkylation / 15.1: desylilation;
DOI:10.1016/S0040-4039(00)00096-4