2-[2-(methylamino)-2-(3-methylthiophen-2-yl)ethyl]aniline

Base Information

• Chemical Name: 2-[2-(methylamino)-2-(3-methylthiophen-2-yl)ethyl]aniline
• CAS No.: 124415-67-4
• Molecular Formula: C₁₄H₁₈N₂S
• Molecular Weight: 246.376
• Mol file: 124415-67-4.mol

Synonyms:AR-R15366

Chemical Property of 2-[2-(methylamino)-2-(3-methylthiophen-2-yl)ethyl]aniline

Chemical Property:

• Vapor Pressure: 4.88E-06mmHg at 25°C
• Boiling Point: 382°Cat760mmHg
• Flash Point: 184.8°C
• Density: 1.135g/cm³

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[2-(methylamino)-2-(3-methylthiophen-2-yl)ethyl]aniline

There total 3 articles about 2-[2-(methylamino)-2-(3-methylthiophen-2-yl)ethyl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-2,2-dimethyl-N-<2-<2-(methylamino)-2-(3-methyl-2-thienyl)ethyl>phenyl>propanamide (124415-83-4) → (+/-)-2-amino-N-methyl-α-(3-methyl-2-thienyl)benzeneethanamine (146645-51-4,146645-52-5,124415-67-4)

Guidance literature:

With hydrogenchloride; at 100 ℃; for 24h;

DOI:10.1021/jm00045a004

Reference yield:

2,2-dimethyl-N-(2-methylphenyl)propanamide (61495-04-3) → (+/-)-2-amino-N-methyl-α-(3-methyl-2-thienyl)benzeneethanamine (146645-51-4,146645-52-5,124415-67-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) hexane, THF, 2-10 deg C, 1 h, 2.) hexane, THF, 0-10 deg C, 1 h

2: 6 N HCl / 24 h / 100 °C

With hydrogenchloride; n-butyllithium;

DOI:10.1021/jm00045a004

Reference yield:

3-methyl-2-thiophenecarboxaldehyde methylimine → (+/-)-2-amino-N-methyl-α-(3-methyl-2-thienyl)benzeneethanamine (146645-51-4,146645-52-5,124415-67-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) hexane, THF, 2-10 deg C, 1 h, 2.) hexane, THF, 0-10 deg C, 1 h

2: 6 N HCl / 24 h / 100 °C

With hydrogenchloride; n-butyllithium;

DOI:10.1021/jm00045a004

upstream raw materials:

(+/-)-2,2-dimethyl-N-<2-<2-(methylamino)-2-(3-methyl-2-thienyl)ethyl>phenyl>propanamide

2,2-dimethyl-N-(2-methylphenyl)propanamide

Downstream raw materials:

(+/-)-2-amino-N-formyl-N-methyl-α-(3-methyl-2-thienyl)benzeneethanamine

(+/-)-N-<2-<2-(N-formyl-N-methylamino)-2-(3-methyl-2-thienyl)ethyl>phenyl>formamide

(+/-)-2-amino-N,N-dimethyl-α-(3-methyl-2-thienyl)benzeneethanamine

Refernces

• 1、 -. "4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines". . . Retrieved 2008/06/13.