Cyclopropanecarboxylic acid, 1-amino-2-ethyl- (9CI)

Base Information

• Chemical Name: Cyclopropanecarboxylic acid, 1-amino-2-ethyl- (9CI)
• CAS No.: 80483-77-8
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.159
• Mol file: 80483-77-8.mol

Synonyms:1-amino-2-ethylcyclopropane-1-carboxylic acid

Chemical Property of Cyclopropanecarboxylic acid, 1-amino-2-ethyl- (9CI)

Chemical Property:

• Vapor Pressure: 0.0146mmHg at 25°C
• Boiling Point: 238.1°C at 760 mmHg
• Flash Point: 97.8°C
• PSA: 0.00000
• Density: 1.184g/cm³
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopropanecarboxylic acid, 1-amino-2-ethyl- (9CI)

There total 26 articles about Cyclopropanecarboxylic acid, 1-amino-2-ethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(+/-)-(E)-1-amino-2-ethylcyclopropanecarbonitrile hydrochloride → (+/-)-(E)-1-amino-2-ethylcyclopropanecarboxylic acid (63364-56-7,63364-60-3,63393-56-6,63393-57-7,65878-52-6,65878-53-7,65878-54-8,80483-77-8,87480-58-8,93453-13-5)

Guidance literature:

With hydrogenchloride; for 15h; Heating;

DOI:10.1021/jo982528g

Reference yield: 96.0%

1-Azido-2-ethyl-cyclopropanecarboxylic acid (87429-76-3) → (1R,2S- and 1S,2R)-2-ethyl-1-aminocyclopropane-1-carboxylic acid (63364-56-7,63364-60-3,63393-56-6,63393-57-7,65878-52-6,65878-53-7,65878-54-8,80483-77-8,87480-58-8,93453-13-5)

Guidance literature:

With hydrogen;

DOI:10.1016/S0040-4039(00)87272-X

Reference yield: 80.0%

(Z)-methyl 1-amino-2-ethylcyclopropanecarboxylate → (1R,2S- and 1S,2R)-2-ethyl-1-aminocyclopropane-1-carboxylic acid (63364-56-7,63364-60-3,63393-56-6,63393-57-7,65878-52-6,65878-53-7,65878-54-8,80483-77-8,87480-58-8,93453-13-5)

Guidance literature:

With hydrogenchloride; water; for 1h; Heating;

DOI:10.1002/1099-0690(200207)2002:13<2160::AID-EJOC2160>3.0.CO;2-1

upstream raw materials:

1-Azido-2-ethyl-cyclopropanecarboxylic acid

1,1-dimethyl 2-ethylcyclopropane-1,1-dicarboxylate

Methyl (Z)-2-azido-pentenoate

2-ethylcyclopropane-1,1-dicarboxylic acid di-tert-butyl ester

Downstream raw materials:

(1S,2R)-1-((S)-2-Ethoxycarbonyloxy-2-phenyl-acetylamino)-2-ethyl-cyclopropanecarboxylic acid methyl ester

(1S,2R)-1-((R)-2-Ethoxycarbonyloxy-2-phenyl-acetylamino)-2-ethyl-cyclopropanecarboxylic acid methyl ester

(1R,2S)-1-((S)-2-Ethoxycarbonyloxy-2-phenyl-acetylamino)-2-ethyl-cyclopropanecarboxylic acid methyl ester

(+)-(1S,2R)-allocoronamic acid

Refernces

• 1、 Kozyrkov,Pukin,Kulinkovich,Ollivier,Salaun. "A convenient approach to substituted 1-(1-alkenyl)cyclopropanols: A new preparation of 2,3-methanoamino acids". . p. 6399 - 6402. Retrieved 2007/10/03.
• 2、 Dorizon, Philippe,Su, Guifa,Ludvig, Gitte,Nikitina, Lilyia,Paugam, Renee,Ollivier, Jean,Salauen, Jacques. "Stereoselective synthesis of highly functionalized cyclopropanes. Application to the asymmetric synthesis of (1S,2S)-2,3-methanoamino acids". . p. 4712 - 4724. Retrieved 2007/10/03.