Base Information
- Chemical Name:Bacillus cereus
- CAS No.:68038-62-0
- Molecular Formula:
- Molecular Weight:0
- Hs Code.:
Synonyms:
Synonyms:
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The research aimed to synthesize and evaluate the anti-microbial properties of 2-methyl-3-substituted-4(3H)-quinazolinones, a class of quinazolinone derivatives known for their broad spectrum of biological activities, including anti-microbial effects. The study focused on derivatives with a thiazoline or thiazolidinedione moiety at the 3-position, which were hypothesized to exhibit anti-bacterial and anti-fungal activities. The synthesis involved the use of 3-amino-2-methyl-4(3H)-quinazolinone and various alkyl-, aryl-, or aralkylisothiocyanates to form 2-methyl-3-substituted thiocarbamoylamino-4(3H)-quinazolinones, which were then cyclized to form thiazoline and thiazolidinone derivatives. The anti-microbial activity of these compounds was tested against Gram-positive and Gram-negative bacteria. The results were generally discouraging, with most compounds showing little activity, but some, like compounds 5, 8, 10, and 11, exhibited higher activity against Gram-positive bacteria. Notably, compounds 5 and 8 were equipotent, and compounds 11 and 12 were more potent against Bacillus cereus compared to the reference standard, penicillin G. The study concluded that while the majority of the synthesized compounds did not show promising anti-microbial activity, a few specific derivatives demonstrated potential as anti-microbial agents.
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