Chlorambucil half mustard

Base Information

• Chemical Name: Chlorambucil half mustard
• CAS No.: 116505-53-4
• Molecular Formula: C₁₂H₁₆ClNO₂
• Molecular Weight: 241.718
• Mol file: 116505-53-4.mol

Synonyms:Chlorambucil half mustard

Chemical Property of Chlorambucil half mustard

Chemical Property:

• Vapor Pressure: 5.32E-08mmHg at 25°C
• Boiling Point: 425.5°C at 760 mmHg
• Flash Point: 211.2°C
• PSA: 49.33000
• Density: 1.225g/cm³
• LogP: 2.81760

Purity/Quality:

90%+ ^*data from raw suppliers

N-Des-(2-chloroethyl)Chlorambucil ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Des-(2-chloroethyl) Chlorambucil is the half-mustard analog of Chlorambucil (C325050) and exhibits mutagenic activity.

Technology Process of Chlorambucil half mustard

There total 2 articles about Chlorambucil half mustard which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

→ 4-[(2'-chloroethyl)amino]-phenylbutyric acid (116505-53-4)

Guidance literature:

Reference yield: 7.0%

chlorambucil N-oxide hydrochloride → 4-[(2'-chloroethyl)amino]-phenylbutyric acid (116505-53-4) + 4-<4'-phenyl>butanoic acid

Guidance literature:

With phosphate buffer pH 7.4; In methanol; at 20 ℃; for 15h;

DOI:10.1021/jm00007a021

Refernces

• 1、 -. "COMPOUNDS AND METHODS USEFUL FOR TREATMENT OF DISEASES MEDIATED BY HIF-1". Page/Page column 77. . Retrieved 2012/05/19.