Acetamide, N-(4-(((2,6-dimethoxy-4-pyrimidinyl)amino)sulfonyl)phenyl)-

Base Information

• Chemical Name: Acetamide, N-(4-(((2,6-dimethoxy-4-pyrimidinyl)amino)sulfonyl)phenyl)-
• CAS No.: 555-25-9
• Molecular Formula: C14H16N4O5S
• Molecular Weight: 352.371
• European Community (EC) Number: 611-280-4
• UNII: 9K98HZI4W8
• DSSTox Substance ID: DTXSID10204077
• Nikkaji Number: J29.010F
• Wikidata: Q83077532
• Metabolomics Workbench ID: 78553
• ChEMBL ID: CHEMBL1349361
• Mol file: 555-25-9.mol

Synonyms:555-25-9;N4-Acetylsulfadimethoxine;Sulfadimethoxine N4-Acetate;Acetamide, N-(4-(((2,6-dimethoxy-4-pyrimidinyl)amino)sulfonyl)phenyl)-;N-[4-[(2,6-dimethoxypyrimidin-4-yl)sulfamoyl]phenyl]acetamide;9K98HZI4W8;UNII-9K98HZI4W8;N-(4-(((2,6-Dimethoxy-4-pyrimidinyl)amino)sulfonyl)phenyl)acetamide;C14H16N4O5S;4-(Acetylamino)-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide;Acetylsulfadimethoxine;N-{4-[(2,6-dimethoxypyrimidin-4-yl)sulfamoyl]phenyl}acetamide;N-(4-((2,6-DIMETHOXYPYRIMIDIN-4-YL)SULFAMOYL)PHENYL)ACETAMIDE;N-(4-{[(2,6-dimethoxy-4-pyrimidinyl)amino]sulfonyl}phenyl)acetamide;N-[4-[[(2,6-Dimethoxy-4-pyrimidinyl)amino]sulfonyl]phenyl]acetamide;N4-Acetylsulphadimethoxine;Oprea1_011961;Oprea1_678202;MLS000123077;CHEMBL1349361;DTXSID10204077;BDBM223484;HMS2438L15;N-[4-(2,6-Dimethoxy-pyrimidin-4-ylsulfamoyl)-phenyl]-acetamide;MFCD00580046;STK834145;AKOS000747068;N4-ACETYLSULFADIMETHOXYPYRIMIDINE;NCGC00245475-01;SMR000123686;N4-Acetylsulfadimethoxine, analytical standard;SULFADIMETHOXINE IMPURITYB [EP IMPURITY];US9320734, 450;N4-ACETYL-2,4-DIMETHOXY-6-SULFANILAMIDOPYRIMIDINE;N4-Acetyl-N1-(4,6-dimethoxy-2-pyrimidinyl)sulfanilamide;N-[4-(2,6-Dimethoxypyrimidin-4-ylsulfamoyl)phenyl]acetamide;4-Acetylamino-N-(4,6-dimethoxy-pyrimidin-2-yl)benzenesulfonamide;ACETANILIDE, 4'-((2,6-DIMETHOXY-4-PYRIMIDINYL)SULFAMOYL)-;N-(p-(2,6-Dimethoxy-4-pyrimidinylaminosulfonyl)phenyl)acetamide;N-(4-([(2,6-Dimethoxy-4-pyrimidinyl)amino]sulfonyl)phenyl)acetamide #;SULFADIMETHOXINE SODIUM FOR VETERINARY USE IMPURITY B [EP IMPURITY]

Chemical Property of Acetamide, N-(4-(((2,6-dimethoxy-4-pyrimidinyl)amino)sulfonyl)phenyl)-

Chemical Property:

• Refractive Index: 1.6000 (estimate)
• PSA: 131.38000
• Density: 1.431g/cm³
• LogP: 3.05630
• Water Solubility.: 0.19g/L(temperature not stated)
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 6
• Exact Mass: 352.08414080
• Heavy Atom Count: 24
• Complexity: 516

Purity/Quality:

98% ^*data from raw suppliers

SulfadimethoxineN4-Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=NC(=N2)OC)OC
• Uses: Sulfadimethoxine N4-Acetate (Sulfadimethoxine EP Impurity B) is a derivative of Sulfadimethoxine (S699060), a long-acting sulfonamide antibacterial that is frequently used in combination with Ormetoprim to prevent the spread of disease in freshwater aquaculture.

Technology Process of Acetamide, N-(4-(((2,6-dimethoxy-4-pyrimidinyl)amino)sulfonyl)phenyl)-

There total 4 articles about Acetamide, N-(4-(((2,6-dimethoxy-4-pyrimidinyl)amino)sulfonyl)phenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,6-dimethoxypyrimidin-4-amine (3289-50-7) + p-acetylaminobenzenesulfonyl chloride (121-60-8) → 4-p-acetamidobenzenesulfonamido-2,6-dimethoxypyrimidine (555-25-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 15 ℃; for 14h; Temperature; Large scale;

Reference yield:

acetic anhydride (108-24-7) + sulfadimethoxine sodium salt → 4-p-acetamidobenzenesulfonamido-2,6-dimethoxypyrimidine (555-25-9)

Guidance literature:

With sulfuric acid; In acetone;

DOI:10.1016/j.chemosphere.2004.07.017

Reference yield:

→ 4-p-acetamidobenzenesulfonamido-2,6-dimethoxypyrimidine (555-25-9)

Guidance literature:

DOI:10.1007/BF00903598

upstream raw materials:

2,6-dimethoxypyrimidin-4-amine

p-acetylaminobenzenesulfonyl chloride

acetic anhydride

Downstream raw materials:

sulfadimethoxine

Refernces

• 1、 Eguchi, Kaoru,Nagase, Hiroyasu,Ozawa, Manao,Endoh, Yuuko S.,Goto, Kisako,Hirata, Kazumasa,Miyamoto, Kazuhisa,Yoshimura, Haruo. "Evaluation of antimicrobial agents for veterinary use in the ecotoxicity test using microalgae". . p. 1733 - 1738. Retrieved 2007/10/03.