4H-Imidazo[2,1-c][1,4]benzoxazine

Base Information

• Chemical Name: 4H-Imidazo[2,1-c][1,4]benzoxazine
• CAS No.: 82296-08-0
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.186
• Mol file: 82296-08-0.mol

Synonyms:

Chemical Property of 4H-Imidazo[2,1-c][1,4]benzoxazine

Chemical Property:

• Vapor Pressure: 6.92E-06mmHg at 25°C
• Boiling Point: 377.1°Cat760mmHg
• Flash Point: 181.9°C
• Density: 1.32g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-Imidazo[2,1-c][1,4]benzoxazine

There total 10 articles about 4H-Imidazo[2,1-c][1,4]benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4H-imidazo<2,1-c><1,4>benzoxazine-2-carboxylic acid (65565-73-3) → 4H-imidazo<2,1-c><1,4>benzoxazine (82296-08-0)

Guidance literature:

for 0.166667h; t > 260 deg C;

Reference yield: 62.0%

N-(2H-1,4-benzoxazin-3-yl)aminoacetaldehyde dimethyl acetal (121608-17-1) → 4H-imidazo<2,1-c><1,4>benzoxazine (82296-08-0)

Guidance literature:

With hydrogenchloride; In methanol; for 2h; Heating;

Reference yield:

(2Z)-[2-oxo-2H-1,4-benzoxazine-3(4H)-ylidene]acetic acid methyl ester (66628-73-7) → 4H-imidazo<2,1-c><1,4>benzoxazine (82296-08-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 83 percent / pentyl nitrite, trichloroacetic acid / acetic acid / 1.) 2h, 2.) 0 deg C, 3 h

2: 88 percent / H₂ / platinum oxide / tetrahydrofuran / 1.5 h / 3040 Torr

3: 79 percent / dimethylformamide / 2 h / Ambient temperature

4: 69 percent / 1.) H₂O, acetone, sodium carbonate, 2.) HCl / 1.) water-bath, 0.25 h, 2.) pH=2

5: 83 percent / 0.33 h / 175 - 180 °C

6: 91 percent / H₂O, NaOH / methanol / 2 h / water-bath

7: 88 percent / 0.17 h / t > 260 deg C

With hydrogenchloride; sodium hydroxide; n-Amyl nitrite; water; hydrogen; sodium carbonate; acetone; trichloroacetic acid; platinum(IV) oxide; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide;

upstream raw materials:

N-(2H-1,4-benzoxazin-3-yl)aminoacetaldehyde dimethyl acetal

4H-imidazo<2,1-c><1,4>benzoxazine-2-carboxylic acid

2-methoxycarbonyl-4H-imidazo<2,1-c><1,4>benzoxazine-1-carboxylic acid

(2Z)-[2-oxo-2H-1,4-benzoxazine-3(4H)-ylidene]acetic acid methyl ester