3,5-Dichlorophenylhydrazine hydrochloride

Base Information

• Chemical Name: 3,5-Dichlorophenylhydrazine hydrochloride
• CAS No.: 63352-99-8
• Molecular Formula: C6H6Cl2N2^.HCl
• Molecular Weight: 213.494
• Hs Code.: 29280000
• European Community (EC) Number: 264-109-7
• DSSTox Substance ID: DTXSID20212744
• Mol file: 63352-99-8.mol

Synonyms:3,5-Dichlorophenylhydrazine hydrochloride;63352-99-8;(3,5-dichlorophenyl)hydrazine hydrochloride;(3,5-Dichlorophenyl)hydrazine monohydrochloride;3,5-Dichlorophenylhydrazine HCl;(3,5-dichlorophenyl)hydrazine;hydrochloride;Hydrazine, (3,5-dichlorophenyl)-, monohydrochloride;57396-93-7;EINECS 264-109-7;MFCD00012938;3,5-Dichlorophenylhydrazine hydrochloride, tech.;Hydrazine, (3,5-dichlorophenyl)-, hydrochloride (1:);(3,5-DICHLOROPHENYL)HYDRAZINE HCL;1-(3,5-dichlorophenyl)hydrazine hydrochloride;SCHEMBL379523;DTXSID20212744;BDXZOJVMTJOAPS-UHFFFAOYSA-N;AKOS005254460;AS-9402;CS-W014964;SY022151;3,5-dichloro-phenylhydrazine hydrochloride;A8729;AM20060918;D2644;FT-0614572;3,5-Dichlorophenylhydrazine hydrochloride, 95%;EN300-170583;Hydrazine, (3,5-dichlorophenyl)-, hydrochloride (1:?)

Chemical Property of 3,5-Dichlorophenylhydrazine hydrochloride

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.0027mmHg at 25°C
• Melting Point: 208-210 °C (dec.)(lit.)
• Boiling Point: 286.1 °C at 760 mmHg
• Flash Point: 126.8 °C
• PSA: 38.05000
• LogP: 3.85430
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 211.967481
• Heavy Atom Count: 11
• Complexity: 99.9

Purity/Quality:

99% ^*data from raw suppliers

3,5-Dichlorophenylhydrazine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-37/39-36/37/39-22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(C=C1Cl)Cl)NN.Cl
• Uses: 3,5-Dichlorophenylhydrazine hydrochloride was used to prepare [2-(3,5-dichlorophenyl)-1,1-dioxo-2,3-dihydro-1H-1λ6-[1,2,3,5]thiatriazol-4-yl]dimethylamine.

Technology Process of 3,5-Dichlorophenylhydrazine hydrochloride

There total 2 articles about 3,5-Dichlorophenylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-bromo-3,5-dichlorobenzene (19752-55-7) → (3,5-dichlorophenyl)hydrazine hydrochloride (63352-99-8)

Guidance literature:

1-bromo-3,5-dichlorobenzene; With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide; In water; at 80 ℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;

With hydrazine hydrate; In water; at 80 ℃; Inert atmosphere; Schlenk technique; Sealed tube;

With hydrogenchloride; In water; pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/cjoc.201800326

Reference yield:

(3R,4S)-4-hydroxy-2-oxotetrahydrofuran-3-yl 2-(2-(3,5-dichlorophenyl)hydrazinyl)-2-oxoethanoate (1352877-25-8) → (3,5-dichlorophenyl)hydrazine hydrochloride (63352-99-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 90 ℃; for 2h;

DOI:10.1016/j.tet.2011.09.146

Reference yield: 97.0%

(3,5-dichlorophenyl)hydrazine hydrochloride (63352-99-8) → 1-bromo-3,5-dichlorobenzene (19752-55-7)

Guidance literature:

With boron tribromide; dimethyl sulfoxide; at 80 ℃; for 1h;

DOI:10.1016/j.tetlet.2020.151959

upstream raw materials:

(3R,4S)-4-hydroxy-2-oxotetrahydrofuran-3-yl 2-(2-(3,5-dichlorophenyl)hydrazinyl)-2-oxoethanoate

1-bromo-3,5-dichlorobenzene

Downstream raw materials:

(E)-ethyl 2-(2-(3,5-dichlorophenyl)hydrazono)propanoate

N-(3,5-Dichloro-phenyl)-N'-[2,2,2-trifluoro-1-phenyl-eth-(Z)-ylidene]-hydrazine

N-[Bis-(4-methoxy-phenyl)-methylene]-N'-(3,5-dichloro-phenyl)-hydrazine

4-{1-[(3,5-Dichloro-phenyl)-hydrazono]-ethyl}-benzonitrile

Refernces

• 1、 Browne, Duncan L.,Baxendale, Ian R.,Ley, Steven V.. "Piecing together the puzzle: Understanding a mild, metal free reduction method for the large scale synthesis of hydrazines". supporting information; experimental part. p. 10296 - 10303. Retrieved 2012/01/04.