2H-Benzimidazol-2-one,1-[1-[1-(4-chlorophenyl)ethyl]-4-piperidinyl]-1,3-dihydro-

Base Information

• Chemical Name: 2H-Benzimidazol-2-one,1-[1-[1-(4-chlorophenyl)ethyl]-4-piperidinyl]-1,3-dihydro-
• CAS No.: 6440-26-2
• Molecular Formula: C₂₀H₂₂ClN₃O
• Molecular Weight: 355.867

Synonyms:2-Benzimidazolinone,1-[1-(p-chloro-a-methylbenzyl)-4-piperidyl]-(8CI); R 6582

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 2H-Benzimidazol-2-one,1-[1-[1-(4-chlorophenyl)ethyl]-4-piperidinyl]-1,3-dihydro-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Benzimidazol-2-one,1-[1-[1-(4-chlorophenyl)ethyl]-4-piperidinyl]-1,3-dihydro-

There total 2 articles about 2H-Benzimidazol-2-one,1-[1-[1-(4-chlorophenyl)ethyl]-4-piperidinyl]-1,3-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

para-chloroacetophenone (99-91-2) + 4-(2-keto-1-benzimidazolinyl)piperidine (20662-53-7) → 1-(1-(1-(4-chlorophenyl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one (6440-26-2)

Guidance literature:

para-chloroacetophenone; 4-(2-keto-1-benzimidazolinyl)piperidine; With titanium(IV) isopropylate; In tetrahydrofuran; at 80 ℃; for 5h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/acs.jmedchem.8b01136

Reference yield:

→ 1-(1-(1-(4-chlorophenyl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one (6440-26-2)

Guidance literature:

Aus d. NH-Verb. durch Alkyl.;

upstream raw materials:

para-chloroacetophenone

4-(2-keto-1-benzimidazolinyl)piperidine