Diethyl (((3-(2,6-dimethyl-4-pyridinyl)-4-fluorophenyl)amino)methylene )propanedioate

Base Information

Chemical Name:Diethyl (((3-(2,6-dimethyl-4-pyridinyl)-4-fluorophenyl)amino)methylene )propanedioate
CAS No.:104431-74-5
Molecular Formula:C21H23 F N2 O4
Molecular Weight:0
Hs Code.:
Mol file:104431-74-5.mol

Synonyms:Propanedioicacid, [[[3-(2,6-dimethyl-4-pyridinyl)-4-fluorophenyl]amino]methylene]-, diethylester (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Diethyl (((3-(2,6-dimethyl-4-pyridinyl)-4-fluorophenyl)amino)methylene )propanedioate

Chemical Property:

Vapor Pressure:4.01E-08mmHg at 25°C
Boiling Point:445.3°Cat760mmHg
Flash Point:223.1°C
PSA：77.52000
Density:1.207g/cm³
LogP:3.99950

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Diethyl (((3-(2,6-dimethyl-4-pyridinyl)-4-fluorophenyl)amino)methylene )propanedioate

There total 5 articles about Diethyl (((3-(2,6-dimethyl-4-pyridinyl)-4-fluorophenyl)amino)methylene )propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 104431-73-4
3-(2,6-dimethyl-4-pyridinyl)-4-fluorobenzeneamine

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 104431-74-5
diethyl 4-fluoro-3-(2,6-dimethyl-4-pyridinyl)anilinomethylenemalonate

Guidance literature:: In toluene; at 130 - 135 ℃; for 3.5h;
DOI:10.1021/jm00163a021

Reference yield:

: 104431-76-7
4-(2-fluorophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid

: 104431-74-5
diethyl 4-fluoro-3-(2,6-dimethyl-4-pyridinyl)anilinomethylenemalonate

Guidance literature:: Multi-step reaction with 4 steps

1: 42 percent / various solvent(s) / 0.83 h / Heating

2: 1.) conc. sulfuric acid, potassium nitrate / 1.) 0 deg C, 1 h, 2.) from 0 deg C to RT, 5 h

3: 89 percent / H₂ / platinum oxide / ethanol / 4 h

4: 74 percent / toluene / 3.5 h / 130 - 135 °C

With sulfuric acid; hydrogen; potassium nitrate; platinum(IV) oxide; In ethanol; toluene;
DOI:10.1021/jm00163a021

Reference yield:

: 104431-82-5
dimethyl 4-(2-fluorophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylate

: 104431-74-5
diethyl 4-fluoro-3-(2,6-dimethyl-4-pyridinyl)anilinomethylenemalonate

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / 35percent aq. sodium hydroxide / methanol / 5 h / Heating

2: 42 percent / various solvent(s) / 0.83 h / Heating

3: 1.) conc. sulfuric acid, potassium nitrate / 1.) 0 deg C, 1 h, 2.) from 0 deg C to RT, 5 h

4: 89 percent / H₂ / platinum oxide / ethanol / 4 h

5: 74 percent / toluene / 3.5 h / 130 - 135 °C

With sodium hydroxide; sulfuric acid; hydrogen; potassium nitrate; platinum(IV) oxide; In methanol; ethanol; toluene;
DOI:10.1021/jm00163a021