(7Z)-7-(hydroxyimino)-6-methoxy-5-methyl-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one

Base Information

• Chemical Name: (7Z)-7-(hydroxyimino)-6-methoxy-5-methyl-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
• CAS No.: 126221-76-9
• Molecular Formula: C27H22N4O4
• Molecular Weight: 466.488
• Mol file: 126221-76-9.mol

Synonyms:9,13-Epoxy-1H,11H-diindolo[1,2,3-gh:3',2',1'- lm]pyrrolo[3,4-j][1,7]benzodiazonine-1,11- dione,2,3,9,10,12,13-hexahydro-10-methoxy- 9-methyl-,11-oxime,(9S,10R,11Z,13R)-;Tan-1030A;9,13-Epoxy-1H,9H-diindolo(1,2,3-gh:3,2,1-lm)pyrrolo(3,4-j)(1,7)benzodiazonine-1,11(10H)-dione, 2,3,12,13-tetrahydro-10-methoxy-9-methyl-, 11-oxime;

Chemical Property of (7Z)-7-(hydroxyimino)-6-methoxy-5-methyl-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.848
• Boiling Point: 728.8°Cat760mmHg
• Flash Point: 394.5°C
• Density: 1.66g/cm³

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (7Z)-7-(hydroxyimino)-6-methoxy-5-methyl-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one

There total 7 articles about (7Z)-7-(hydroxyimino)-6-methoxy-5-methyl-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

C34H28N4O4 (195617-15-3) → TAN-1030A (126221-76-9)

Guidance literature:

With trimethylsilyl iodide; In chloroform-d1; for 48h; Ambient temperature;

DOI:10.1021/ja971304x

Reference yield:

C36H31N3O7 (188028-91-3) → TAN-1030A (126221-76-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 89 percent / LiBH₄ / tetrahydrofuran / 0.33 h

2: 71 percent / pyridinium trifluoroacetate, 1,3-dicyclohexylcarbodiimide / benzene; dimethylsulfoxide / 9 h / Ambient temperature

3: 85 percent / BF₃*OEt₂ / diethyl ether / 24 h / 25 - 30 °C

4: 85 percent / NaOAc / aq. ethanol / 0.5 h / Heating

5: 68 percent / KOH, n-Bu₄NBr / tetrahydrofuran / 0.5 h

6: 25 percent / anisole, TFA / 24 h

7: 24 percent / iodotrimethylsilane / CDCl₃ / 48 h / Ambient temperature

With potassium hydroxide; lithium borohydride; trimethylsilyl iodide; boron trifluoride diethyl etherate; tetrabutylammomium bromide; sodium acetate; pyridinium trifluroacetate; methoxybenzene; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; chloroform-d1; ethanol; dimethyl sulfoxide; benzene;

DOI:10.1021/ja971304x

Reference yield:

C35H31N3O6 (188028-23-1) → TAN-1030A (126221-76-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 71 percent / pyridinium trifluoroacetate, 1,3-dicyclohexylcarbodiimide / benzene; dimethylsulfoxide / 9 h / Ambient temperature

2: 85 percent / BF₃*OEt₂ / diethyl ether / 24 h / 25 - 30 °C

3: 85 percent / NaOAc / aq. ethanol / 0.5 h / Heating

4: 68 percent / KOH, n-Bu₄NBr / tetrahydrofuran / 0.5 h

5: 25 percent / anisole, TFA / 24 h

6: 24 percent / iodotrimethylsilane / CDCl₃ / 48 h / Ambient temperature

With potassium hydroxide; trimethylsilyl iodide; boron trifluoride diethyl etherate; tetrabutylammomium bromide; sodium acetate; pyridinium trifluroacetate; methoxybenzene; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; chloroform-d1; ethanol; dimethyl sulfoxide; benzene;

DOI:10.1021/ja971304x

upstream raw materials:

C₃₄H₂₈N₄O₄

C₃₆H₃₁N₃O₇

C₃₅H₃₁N₃O₆

C₃₅H₂₉N₃O₆