(5-p-Tolylamino-[1,3,4]thiadiazol-2-ylsulfanyl)-acetic acid hydrazide

Base Information

• Chemical Name: (5-p-Tolylamino-[1,3,4]thiadiazol-2-ylsulfanyl)-acetic acid hydrazide
• CAS No.: 52494-24-3
• Molecular Formula: C₁₁H₁₃N₅OS₂
• Molecular Weight: 295.389
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID40368419
• Wikidata: Q82154944
• Mol file: 52494-24-3.mol

Synonyms:52494-24-3;(5-p-Tolylamino-[1,3,4]thiadiazol-2-ylsulfanyl)-acetic acid hydrazide;2-((5-(p-Tolylamino)-1,3,4-thiadiazol-2-yl)thio)acetohydrazide;2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetohydrazide;2-({5-[(4-methylphenyl)amino]-1,3,4-thiadiazol-2-yl}sulfanyl)acetohydrazide;2-{[5-(4-Methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl}acetohydrazide;DTXSID40368419;AKOS027378120;CS-0219698;EN300-04710;SR-01000037966;J-501616;SR-01000037966-1;Z56870714

Chemical Property of (5-p-Tolylamino-[1,3,4]thiadiazol-2-ylsulfanyl)-acetic acid hydrazide

Chemical Property:

• PSA: 149.96000
• Density: 1.44g/cm³
• LogP: 3.28570
• XLogP3: 2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 295.05615240
• Heavy Atom Count: 19
• Complexity: 299

Purity/Quality:

98%Min ^*data from raw suppliers

(5-P-TOLYLAMINO-[1,3,4]THIADIAZOL-2-YLSULFANYL)-ACETIC ACID HYDRAZIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)NC2=NN=C(S2)SCC(=O)NN

Technology Process of (5-p-Tolylamino-[1,3,4]thiadiazol-2-ylsulfanyl)-acetic acid hydrazide

There total 2 articles about (5-p-Tolylamino-[1,3,4]thiadiazol-2-ylsulfanyl)-acetic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[5-(4-methyl-anilino)-[1,3,4]thiadiazol-2-ylsulfanyl]-acetic acid ethyl ester (52494-18-5) → [5-(4-methyl-anilino)-[1,3,4]thiadiazol-2-ylsulfanyl]-acetic acid hydrazide (52494-24-3)

Guidance literature:

With hydrazine hydrate; In ethanol;

Reference yield:

5-(p-methylphenylamino)-1,3,4-thiadiazolium-2-thiolate (14731-25-0) → [5-(4-methyl-anilino)-[1,3,4]thiadiazol-2-ylsulfanyl]-acetic acid hydrazide (52494-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / ethanol / 4 h / Heating

2: hydrazine hydrate / ethanol / 2 h / Heating

With sodium hydroxide; hydrazine hydrate; In ethanol;

Reference yield: 76.0%

[5-(4-methyl-anilino)-[1,3,4]thiadiazol-2-ylsulfanyl]-acetic acid hydrazide (52494-24-3) + 4-chlorobenzaldehyde (104-88-1) → (5-p-Tolylamino-[1,3,4]thiadiazol-2-ylsulfanyl)-acetic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide

Guidance literature:

In ethanol; for 5h; Heating;

upstream raw materials:

[5-(4-methyl-anilino)-[1,3,4]thiadiazol-2-ylsulfanyl]-acetic acid ethyl ester

5-(p-methylphenylamino)-1,3,4-thiadiazolium-2-thiolate

Downstream raw materials:

(5-p-Tolylamino-[1,3,4]thiadiazol-2-ylsulfanyl)-acetic acid [1-(4-methoxy-3-nitro-phenyl)-meth-(E)-ylidene]-hydrazide

(5-p-Tolylamino-[1,3,4]thiadiazol-2-ylsulfanyl)-acetic acid [1-(4-chloro-phenylazo)-1-(4-methoxy-3-nitro-phenyl)-meth-(Z)-ylidene]-hydrazide

(5-p-Tolylamino-[1,3,4]thiadiazol-2-ylsulfanyl)-acetic acid [1-(4-bromo-phenylazo)-1-(4-methoxy-3-nitro-phenyl)-meth-(Z)-ylidene]-hydrazide

(5-p-Tolylamino-[1,3,4]thiadiazol-2-ylsulfanyl)-acetic acid [1-(4-methoxy-3-nitro-phenyl)-1-m-tolylazo-meth-(Z)-ylidene]-hydrazide