2-hydroxyethynylestradiol

Base Information

• Chemical Name: 2-hydroxyethynylestradiol
• CAS No.: 50394-89-3
• Molecular Formula: C₂₀H₂₄O₃
• Molecular Weight: 312.409
• Mol file: 50394-89-3.mol

Synonyms:17a-Ethynyl-2-hydroxyestradiol;19-Nor-17a-pregna-1,3,5(10)-trien-20-yne-2,3,17-triol;2-Hydroxy-17a-ethynyl-17b-estradiol; 2-Hydroxy-17a-ethynylestradiol;2-Hydroxyethinylestradiol

Chemical Property of 2-hydroxyethynylestradiol

Chemical Property:

• Vapor Pressure: 1.91E-10mmHg at 25°C
• Melting Point: 220-223°C
• Boiling Point: 490.7°C at 760 mmHg
• Flash Point: 227.8°C
• PSA: 60.69000
• Density: 1.29g/cm³
• LogP: 3.31820
• Storage Temp.: -20°C Freezer

Purity/Quality:

98%Min ^*data from raw suppliers

2-HydroxyEthynylEstradiol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-hydroxyethynylestradiol

There total 9 articles about 2-hydroxyethynylestradiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

17a-Ethynyl-2-methoxyestradiol (22415-44-7,26011-46-1) → 2-hydroxy-17α-ethynylestradiol (50394-89-3)

Guidance literature:

With boron tribromide; In dichloromethane;

DOI:10.1016/0039-128X(74)90150-0

Reference yield:

2-methoxyestrone (362-08-3,7683-30-9) → 2-hydroxy-17α-ethynylestradiol (50394-89-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂NCH₂CH₂NH₂ / dimethylsulfoxide

2: BBr₃ / CH₂Cl₂

With boron tribromide; ethylenediamine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1016/0039-128X(74)90150-0

Reference yield:

2-Amino-17α-ethynylestradiol → 2-hydroxy-17α-ethynylestradiol (50394-89-3)

Guidance literature:

With hydrogenchloride; sodium periodate; acetic acid;

DOI:10.1016/0039-128X(76)90010-6

upstream raw materials:

ethinyl estradiol

17a-Ethynyl-2-methoxyestradiol

17α-ethinyl-2-nitroestrone

2-methoxyestrone