2-amino-1,9-dihydro-9-(2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-6H-purin-6-one

Base Information

Chemical Name:2-amino-1,9-dihydro-9-(2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-6H-purin-6-one
CAS No.:110289-24-2
Molecular Formula:C₁₁H₁₄FN₅O₃
Molecular Weight:283.262
Hs Code.:
Mol file:110289-24-2.mol

Synonyms:6H-Purin-6-one,2-amino-9-[2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-1,9-dihydro-, (1a,2a,3b,4a)- (9CI); 6H-Purin-6-one,2-amino-9-[2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-1,9-dihydro-, (1a,2a,3b,4a)-(?à)-

Suppliers and Price of 2-amino-1,9-dihydro-9-(2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-6H-purin-6-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-amino-1,9-dihydro-9-(2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-6H-purin-6-one

Chemical Property:

Vapor Pressure:1.26E-18mmHg at 25°C
Boiling Point:665.7°Cat760mmHg
Flash Point:356.4°C
PSA：131.04000
Density:2.01g/cm³
LogP:-0.70350

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses ((+/-)(1''α,2''α,3''β,4''α)-2-Amino-1,9-dihydro-9-[2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-6H-purin-6-one is used in the preparation of Guanine derivatives and their use as virucide.

Technology Process of 2-amino-1,9-dihydro-9-(2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-6H-purin-6-one

There total 16 articles about 2-amino-1,9-dihydro-9-(2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-6H-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 110289-21-9
(+/-)-(1α,2β,3α,4α)-4-<(2-amino-6-chloro-9H-purin-9-yl)amino>-3-fluoro-2-hydroxycyclopentanemethanol

: 110289-24-2
(+/-)-carbocyclic 2'-ara-fluoroguanosine

Guidance literature:: With hydrogenchloride; for 1h; Heating;
DOI:10.1021/jm00107a006

Reference yield:

: 110289-10-6
(+/-)-(1α,2β,3α,4α)-4-<(2-amino-6-chloro-4-pyrimidinyl)amino>-3-fluoro-2-hydroxycyclopentanemethanol

: 110289-24-2
(+/-)-carbocyclic 2'-ara-fluoroguanosine

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid, sodium acetate / H₂O

2: Zn, acetic acid

3: cc. HCl / dimethylformamide

4: 2 M HCl / Heating

5: 76 percent / 1 M HCl / Heating

With hydrogenchloride; sodium acetate; acetic acid; zinc; In water; N,N-dimethyl-formamide;
DOI:10.1039/c39880000656

Reference yield:

: 110289-09-3
(+/-)-(1α,2β,3α,4α)-4-<<2-amino-6-chloro-5-<(4-chlorophenyl)azo>-4-pyrimidinyl>amino>-3-fluoro-2-hydroxycyclopentanemethanol

: 110289-24-2
(+/-)-carbocyclic 2'-ara-fluoroguanosine

Guidance literature:: Multi-step reaction with 4 steps

1: Zn, acetic acid

2: cc. HCl / dimethylformamide

3: 2 M HCl / Heating

4: 76 percent / 1 M HCl / Heating

With hydrogenchloride; acetic acid; zinc; In N,N-dimethyl-formamide;
DOI:10.1039/c39880000656