Cyclopropanecarboxamide, 2-((acetylamino)methyl)-N,N-diethyl-1-phenyl-, cis-

Base Information

Chemical Name:Cyclopropanecarboxamide, 2-((acetylamino)methyl)-N,N-diethyl-1-phenyl-, cis-
CAS No.:105310-24-5
Molecular Formula:C17H24 N2 O2
Molecular Weight:288.3847
Hs Code.:
DSSTox Substance ID:DTXSID80147068
Wikidata:Q76156352

Synonyms:BRN 5974843;Cyclopropanecarboxamide, 2-((acetylamino)methyl)-N,N-diethyl-1-phenyl-, cis-;(Z)-1-Phenyl-2-((acetylamino)methyl)-N,N-diethylcyclopropanecarboxamide;cis-2-((Acetylamino)methyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide;105310-24-5;DTXSID80147068;LS-58528

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclopropanecarboxamide, 2-((acetylamino)methyl)-N,N-diethyl-1-phenyl-, cis-

Chemical Property:

Vapor Pressure:5.54E-10mmHg at 25°C
Boiling Point:496.2°Cat760mmHg
Flash Point:253.9°C
Density:1.092g/cm³
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:288.183778013
Heavy Atom Count:21
Complexity:386

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)C(=O)C1(CC1CNC(=O)C)C2=CC=CC=C2
Isomeric SMILES:CCN(CC)C(=O)[C@@]1(C[C@H]1CNC(=O)C)C2=CC=CC=C2

Technology Process of Cyclopropanecarboxamide, 2-((acetylamino)methyl)-N,N-diethyl-1-phenyl-, cis-

There total 5 articles about Cyclopropanecarboxamide, 2-((acetylamino)methyl)-N,N-diethyl-1-phenyl-, cis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 108-24-7
acetic anhydride

: 105310-09-6,96847-54-0,92623-85-3,96847-55-1
milnacipran

: 105310-24-5
Z-1-phenyl-2-<(acetylamino)methyl>-N,N-diethylcyclopropanecarboxamide

Guidance literature:: With pyridine; Ambient temperature;
DOI:10.1021/jm00385a013

Reference yield:

: 69160-63-0
(1S,2R)/(1R,2S)-2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid

: 105310-24-5
Z-1-phenyl-2-<(acetylamino)methyl>-N,N-diethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / SOCl₂ / 2 h / Heating

2: diethyl ether / Ambient temperature

3: dimethylformamide / 2.5 h / 110 °C

4: H₂NNH₂ / ethanol / Heating

5: 80 percent / pyridine / Ambient temperature

With pyridine; thionyl chloride; hydrazine; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00385a013

Reference yield:

: 105310-66-5
(1S,2R)/(1R,2S)-2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid chloride

: 105310-24-5
Z-1-phenyl-2-<(acetylamino)methyl>-N,N-diethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether / Ambient temperature

2: dimethylformamide / 2.5 h / 110 °C

3: H₂NNH₂ / ethanol / Heating

4: 80 percent / pyridine / Ambient temperature

With pyridine; hydrazine; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00385a013