Morphinan-14-ol, 4,5-alpha-epoxy-3-methoxy-17-methyl-

Base Information

• Chemical Name: Morphinan-14-ol, 4,5-alpha-epoxy-3-methoxy-17-methyl-
• CAS No.: 7387-55-5
• Molecular Formula: C₁₈H₂₃NO₃
• Molecular Weight: 301.386
• DSSTox Substance ID: DTXSID90224455
• Nikkaji Number: J1.397.544B
• Wikidata: Q76309859
• Mol file: 7387-55-5.mol

Synonyms:BRN 0623758;RAM-306;Morphinan-14-ol, 4,5-alpha-epoxy-3-methoxy-17-methyl-;4,5-alpha-Epoxy-3-methoxy-17-methylmorphinan-14-ol;7387-55-5;SCHEMBL18457629;DTXSID90224455;LS-91970;(5alpha)-4,5-Epoxy-3-methoxy-17-methylmorphinan-14-ol

Chemical Property of Morphinan-14-ol, 4,5-alpha-epoxy-3-methoxy-17-methyl-

Chemical Property:

• Vapor Pressure: 4.61E-09mmHg at 25°C
• Boiling Point: 454.8°Cat760mmHg
• Flash Point: 228.9°C
• Density: 1.31g/cm³
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 301.16779360
• Heavy Atom Count: 22
• Complexity: 485

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC23C4CCCC2(C1CC5=C3C(=C(C=C5)OC)O4)O
• Isomeric SMILES: CN1CC[C@]23[C@@H]4CCC[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O

Technology Process of Morphinan-14-ol, 4,5-alpha-epoxy-3-methoxy-17-methyl-

There total 12 articles about Morphinan-14-ol, 4,5-alpha-epoxy-3-methoxy-17-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

14-hydroxycodeinone (508-54-3) → 14-Hydroxy-deoxydihydrocodein (7387-55-5)

Guidance literature:

Multi-step reaction with 5 steps

1: NaBH₄ / dioxane

2: pyridine

4: LiAlH₄ / diethyl ether

5: H₂ / Pt / aq. acetic acid

With sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; platinum; In 1,4-dioxane; pyridine; diethyl ether; acetic acid;

DOI:10.1039/jr9600000773

Reference yield:

14-hydroxycodeine (4829-46-3) → 14-Hydroxy-deoxydihydrocodein (7387-55-5)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine

3: LiAlH₄ / diethyl ether

4: H₂ / Pt / aq. acetic acid

With lithium aluminium tetrahydride; hydrogen; platinum; In pyridine; diethyl ether; acetic acid;

DOI:10.1039/jr9600000773

Reference yield:

14-hydroxycodeine diacatate (103458-67-9) → 14-Hydroxy-deoxydihydrocodein (7387-55-5)

Guidance literature:

Multi-step reaction with 6 steps

1: methanol / Heating

2: KOH / methanol

3: pyridine

5: LiAlH₄ / diethyl ether

6: H₂ / Pt / aq. acetic acid

With potassium hydroxide; lithium aluminium tetrahydride; hydrogen; platinum; In pyridine; methanol; diethyl ether; acetic acid;

DOI:10.1039/jr9600000773

upstream raw materials:

thebaine

4,5α-epoxy-3-methoxy-17-methyl-morphin-7-en-14-ol

14-hydroxycodeinone

14-hydroxycodeine