Isoprenaline sulfate

Base Information

• Chemical Name: Isoprenaline sulfate
• CAS No.: 299-95-6
• Molecular Formula: 2C₁₁H₁₇NO₃*H₂O₄S
• Molecular Weight: 520.601
• Hs Code.: 29072990
• European Community (EC) Number: 206-085-2,629-834-9
• NCI Thesaurus Code: C65983
• Mol file: 299-95-6.mol

Synonyms:Isoprenaline sulfate;Isoprenaline sulphate;Isoproterenol sulfate;6078-56-4;Medihaler-ISO;4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol;sulfuric acid;Isoproterenol sulfate [USP:JAN];1,2-Benzenediol, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, (.+.)-, sulfate (2:1) (salt), dihydrate;Benzyl alcohol, 3,4-dihydroxy-.alpha.-[(isopropylamino)methyl]-, sulfate (2:1) (salt), dihydrate, (.+.)-;SCHEMBL41841;4-(1-Hydroxy-2-(isopropylamino)ethyl)benzene-1,2-diol sulfate;PD052074;Bis[(+/-)-(isopropyl)(beta,3,4-trihydroxyphenethyl)ammonium]sulfate

Chemical Property of Isoprenaline sulfate

Chemical Property:

• Appearance/Colour: COA
• Vapor Pressure: 1.02E-07mmHg at 25°C
• Melting Point: 180 °C
• Boiling Point: 417.5 °C at 760 mmHg
• Flash Point: 179.7 °C
• PSA: 228.42000
• LogP: 3.46820
• Water Solubility.: almost transparency
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 4
• Exact Mass: 309.08822312
• Heavy Atom Count: 20
• Complexity: 268

Purity/Quality:

99% ^*data from raw suppliers

Isoproterenol Sulfate Dihydrate >98.0%(HPLC)(N) ^*data from reagent suppliers

Safty Information:

• Statements: 22
• Safety Statements: 44

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)NCC(C1=CC(=C(C=C1)O)O)O.OS(=O)(=O)O
• Uses: Bronchodilator.
• Therapeutic Function: Bronchodilator

Technology Process of Isoprenaline sulfate

There total 2 articles about Isoprenaline sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.3%

2C11H15NO3*H2O4S (27693-62-5) → 1-(3,4-dihydroxy-phenyl)-2-isopropylamino-ethanol; sulfate (114-45-4,299-95-6,1447-56-9,4675-35-8,6779-80-2,13764-54-0,14609-39-3,17107-57-2,19096-17-4,89699-18-3)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; at 35 ℃; under 3000.3 Torr; Pressure; Temperature; Autoclave;

Reference yield:

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → 1-(3,4-dihydroxy-phenyl)-2-isopropylamino-ethanol; sulfate (114-45-4,299-95-6,1447-56-9,4675-35-8,6779-80-2,13764-54-0,14609-39-3,17107-57-2,19096-17-4,89699-18-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / dichloromethane / 0.5 h / 10 - 15 °C

1.2: 10 h / -10 - 10 °C

2.1: ethanol / 10 h / 10 - 35 °C

2.2: 1 h / pH 2 / Reflux

3.1: 5%-palladium/activated carbon; hydrogen / 35 °C / 3000.3 Torr / Autoclave

With aluminum (III) chloride; 5%-palladium/activated carbon; hydrogen; In ethanol; dichloromethane;

Reference yield:

1-(3,4-dihydroxy-phenyl)-2-isopropylamino-ethanol; sulfate (114-45-4,299-95-6,1447-56-9,4675-35-8,6779-80-2,13764-54-0,14609-39-3,17107-57-2,19096-17-4,89699-18-3) → N-Isopropyl-noradrenochrom (3736-31-0,67491-46-7)

Guidance literature:

With Ac-buffer; acetic acid; In water; electrochemical reaction;

upstream raw materials:

benzene-1,2-diol

2C₁₁H₁₅NO₃*H₂O₄S

Downstream raw materials:

1-isopropyl-indole-3,5,6-triol

N-Isopropyl-noradrenochrom

Refernces