3,4-dihydro-4-oxo-5,6-dimethyl-3-((5,7-difluorobenzothiazol-2-yl)methyl)-1-pyridazineacetic acid

Base Information

Chemical Name:3,4-dihydro-4-oxo-5,6-dimethyl-3-((5,7-difluorobenzothiazol-2-yl)methyl)-1-pyridazineacetic acid
CAS No.:140926-46-1
Molecular Formula:C₁₆H₁₃F₂N₃O₃S
Molecular Weight:365.36
Hs Code.:
Mol file:140926-46-1.mol

Synonyms:3,4-dihydro-4-oxo-5,6-dimethyl-3-((5,7-difluorobenzothiazol-2-yl)methyl)-1-pyridazineacetic acid

Suppliers and Price of 3,4-dihydro-4-oxo-5,6-dimethyl-3-((5,7-difluorobenzothiazol-2-yl)methyl)-1-pyridazineacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,4-dihydro-4-oxo-5,6-dimethyl-3-((5,7-difluorobenzothiazol-2-yl)methyl)-1-pyridazineacetic acid

Chemical Property:

Vapor Pressure:3.27E-12mmHg at 25°C
Boiling Point:533.5°Cat760mmHg
Flash Point:276.4°C
PSA：113.32000
Density:1.44g/cm³
LogP:2.42340

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3,4-dihydro-4-oxo-5,6-dimethyl-3-((5,7-difluorobenzothiazol-2-yl)methyl)-1-pyridazineacetic acid

There total 3 articles about 3,4-dihydro-4-oxo-5,6-dimethyl-3-((5,7-difluorobenzothiazol-2-yl)methyl)-1-pyridazineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 140926-35-8
[1-(5,7-Difluoro-benzothiazol-2-ylmethyl)-4,5-dimethyl-6-oxo-1,6-dihydro-pyridazin-3-yl]-acetic acid tert-butyl ester

: 140926-46-1
3,4-dihydro-4-oxo-5,6-dimethyl-3-<(5,7-difluorobenzothiazol-2-yl)methyl>-1-pyridazineacetic acid

Guidance literature:: With sulfuric acid;
DOI:10.1021/jm00090a002

Reference yield:

: 126764-53-2
2-Chloromethyl-5,7-difluoro-benzothiazole

: 140926-46-1
3,4-dihydro-4-oxo-5,6-dimethyl-3-<(5,7-difluorobenzothiazol-2-yl)methyl>-1-pyridazineacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 2.) DMF

2: conc. H₂SO₄

With sulfuric acid; sodium hydride;
DOI:10.1021/jm00090a002

Reference yield:

: 134972-00-2
tert-butyl (5,6-dimethyl-4-oxopyridin-1-yl)acetate

: 140926-46-1
3,4-dihydro-4-oxo-5,6-dimethyl-3-<(5,7-difluorobenzothiazol-2-yl)methyl>-1-pyridazineacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 2.) DMF

2: conc. H₂SO₄

With sulfuric acid; sodium hydride;
DOI:10.1021/jm00090a002