6-Fluoro-11,17,21-trihydroxy-16-methylpregn-4-ene-3,20-dione

Base Information

Chemical Name:6-Fluoro-11,17,21-trihydroxy-16-methylpregn-4-ene-3,20-dione
CAS No.:387-59-7
Molecular Formula:C22H31 F O5
Molecular Weight:394.484
Hs Code.:
DSSTox Substance ID:DTXSID40959523
Mol file:387-59-7.mol

Synonyms:DTXSID40959523;6-Fluoro-11,17,21-trihydroxy-16-methylpregn-4-ene-3,20-dione

Suppliers and Price of 6-Fluoro-11,17,21-trihydroxy-16-methylpregn-4-ene-3,20-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 6-Fluoro-11,17,21-trihydroxy-16-methylpregn-4-ene-3,20-dione

Chemical Property:

Vapor Pressure:2.33E-15mmHg at 25°C
Boiling Point:569.9°Cat760mmHg
Flash Point:298.4°C
PSA：94.83000
Density:1.29g/cm³
LogP:1.97560
XLogP3:1.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:394.21555225
Heavy Atom Count:28
Complexity:749

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2C3CC(C4=CC(=O)CCC4(C3C(CC2(C1(C(=O)CO)O)C)O)C)F
Isomeric SMILES:C[C@@H]1CC2C3C[C@@H](C4=CC(=O)CCC4(C3C(CC2([C@]1(C(=O)CO)O)C)O)C)F

Technology Process of 6-Fluoro-11,17,21-trihydroxy-16-methylpregn-4-ene-3,20-dione

There total 10 articles about 6-Fluoro-11,17,21-trihydroxy-16-methylpregn-4-ene-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1524-93-2
21-acetoxy-6α-fluoro-11β,17-dihydroxy-16α-methyl-pregn-4-ene-3,20-dione

: 387-59-7
6α-fluoro-11β,17,21-trihydroxy-16α-methyl-pregn-4-ene-3,20-dione

Guidance literature:: With methanol; potassium hydrogencarbonate;
DOI:10.1021/ja01521a088

Reference yield:

: 3862-45-1
21-acetoxy-3,3-ethanediyldioxy-6β-fluoro-16α-methyl-5α-pregn-17(20)t-ene-5,11β-diol

: 387-59-7
6α-fluoro-11β,17,21-trihydroxy-16α-methyl-pregn-4-ene-3,20-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; H₂O₂; OsO₄ / anschliessend mit HCl in CHCl₃ und Aethanol

2: KHCO₃; aqueous methanol

With 4-methyl-morpholine; methanol; osmium(VIII) oxide; dihydrogen peroxide; potassium hydrogencarbonate;
DOI:10.1021/ja01521a088