FLA 908

Base Information

• Chemical Name: FLA 908
• CAS No.: 107188-90-9
• Molecular Formula: C₁₅H₂₁BrN₂O₃
• Molecular Weight: 357.247
• Mol file: 107188-90-9.mol

Synonyms:Benzamide,3-bromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxy-, (?à)-

Chemical Property of FLA 908

Chemical Property:

• Vapor Pressure: 1.33E-08mmHg at 25°C
• Boiling Point: 446.9°Cat760mmHg
• Flash Point: 224.1°C
• PSA: 65.29000
• Density: 1.364g/cm³
• LogP: 2.89010

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FLA 908

There total 5 articles about FLA 908 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

(-)-BZM (84226-04-0) → FLA 797 (84226-14-2) + (-)-FLA 908 (96393-00-9,107188-90-9)

Guidance literature:

With hydrogenchloride; boron tribromide; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/jm00147a025

Reference yield:

N-Ethyl-2-(2,6-dimethoxybenzamidomethyl) pyrrolidine hydrochloride (73219-93-9) → phenol-isomer + N-Ethyl-2-(3-bromo-6-hydroxy-2-methoxybenzamidomethyl)pyrrolidine (107188-90-9)

Guidance literature:

With bromine; boron tribromide; In dichloromethane; water; acetic acid;

Reference yield:

2-6-dimethoxybenzoic acid (1466-76-8) → (-)-FLA 908 (96393-00-9,107188-90-9)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂, DMF / toluene / 1 h / 65 °C

2: 51 percent / CHCl₃ / 0.5 h / 25 °C

3: 51 percent / 3N HCl, BBr₃ / CH₂Cl₂ / 0.5 h / 20 °C

4: 7 percent / 3N HCl, BBr₃ / CH₂Cl₂ / 0.5 h / 20 °C

With hydrogenchloride; thionyl chloride; boron tribromide; N,N-dimethyl-formamide; In dichloromethane; chloroform; toluene;

DOI:10.1021/jm00147a025

upstream raw materials:

(-)-BZM

2-6-dimethoxybenzoic acid

(S)-(-)-N-<(ethyl-2-pyrrolidinyl)methyl>-2,6-dimethoxybenzamide

2,6-dimethoxybenzoyl chloride