Einecs 225-487-9

Base Information

• Chemical Name: Einecs 225-487-9
• CAS No.: 4876-60-2
• Molecular Formula: C₁₀H₂₀N₂*(x)ClH
• Molecular Weight: 241.2
• Hs Code.: 2933399090
• Mol file: 4876-60-2.mol

Synonyms:EINECS 225-487-9;NSC 57799;1,4''-Bipiperidinedihydrochloride

Chemical Property of Einecs 225-487-9

Chemical Property:

• Appearance/Colour: White solid
• Boiling Point: 318.9 °C at 760 mmHg
• Flash Point: 146.7 °C
• PSA: 15.27000
• Density: 0.969g/cm3
• LogP: -1.50500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 203.1315013
• Heavy Atom Count: 13
• Complexity: 124

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,4''-BipiperidineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C2CCNCC2.[Cl-]

Technology Process of Einecs 225-487-9

There total 3 articles about Einecs 225-487-9 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 1,4’-bipiperidine-1’-carboxylate (125541-12-0) → 1,4'-bipiperidine hydrochloride (172281-92-4,4876-60-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1038/onc.2014.225

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 1,4'-bipiperidine hydrochloride (172281-92-4,4876-60-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,2-dichloro-ethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 15 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; In 1,4-dioxane; 1,2-dichloro-ethane;

DOI:10.1038/onc.2014.225

Reference yield:

piperidine (110-89-4) → 1,4'-bipiperidine hydrochloride (172281-92-4,4876-60-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,2-dichloro-ethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 15 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; In 1,4-dioxane; 1,2-dichloro-ethane;

DOI:10.1038/onc.2014.225

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

tert-butyl 1,4’-bipiperidine-1’-carboxylate

piperidine

Refernces